CPLM-022069

Genbank Nucleotide ID

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
52	LPVLQLTKDPLKTPG	ubiquitination	[1, 2, 3, 4, 5, 6]
56	QLTKDPLKTPGRLDH	ubiquitination	[2, 4, 5]
78	HHREQVWKRCINIWR	ubiquitination	[4]
165	AWHPHTNKFAVALLD	ubiquitination	[2, 4]
189	STIVPSLKHRLQRNV	ubiquitination	[2, 4, 5]
301	LWSPDGSKILATTPS	ubiquitination	[1, 2, 3, 4, 5, 6]
366	PERCGEGKGCVGGAK	ubiquitination	[3]
373	KGCVGGAKSATIVAD	ubiquitination	[4]
416	ERLAVLMKGKPRVQD	ubiquitination	[4, 5]
418	LAVLMKGKPRVQDGK	ubiquitination	[4]
425	KPRVQDGKPVILLFR	ubiquitination	[1, 2, 3, 4, 5, 6]

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
[4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]

Functional Description

Plays a role in the normal development of the peripheral and central nervous system.

REPEAT 149 188 WD 1.
REPEAT 191 230 WD 2.
REPEAT 243 282 WD 3.
REPEAT 285 324 WD 4.
MOTIF 544 546 Microbody targeting signal (Potential).
MOD_RES 33 33 Phosphoserine.
MOD_RES 495 495 Phosphoserine.

Alternative splicing; Complete proteome; Disease mutation; Phosphoprotein; Reference proteome; Repeat; WD repeat.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005813; C:centrosome; IDA:HPA.
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0031965; C:nuclear membrane; IDA:HPA.
GO:0005643; C:nuclear pore; IDA:MGI.
GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
GO:0009566; P:fertilization; IEA:Compara.
GO:0015758; P:glucose transport; TAS:Reactome.
GO:0007612; P:learning; IEA:Compara.
GO:0006913; P:nucleocytoplasmic transport; IDA:MGI.
GO:0010827; P:regulation of glucose transport; TAS:Reactome.
GO:0046822; P:regulation of nucleocytoplasmic transport; NAS:UniProtKB.
GO:0044281; P:small molecule metabolic process; TAS:Reactome.
GO:0055085; P:transmembrane transport; TAS:Reactome.
GO:0022415; P:viral reproductive process; TAS:Reactome.

IPR015943; WD40/YVTN_repeat-like_dom.
IPR001680; WD40_repeat.
IPR019775; WD40_repeat_CS.
IPR017986; WD40_repeat_dom.

PS00678; WD_REPEATS_1
PS50082; WD_REPEATS_2
PS50294; WD_REPEATS_REGION