| Tag | Content |
|---|
| CPLM ID | CPLM-000746 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein regulator of cytokinesis 1 |
Protein Synonyms/Alias | |
Gene Name | PRC1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 558 | EFARELSKASKSDAT | ubiquitination | [1] | | 561 | RELSKASKSDATSGI | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. |
Sequence Annotation | REGION 1 341 Dimerization.
REGION 342 466 Spectrin-fold.
REGION 467 620 Unstructured, Arg/Lys rich.
BINDING 377 377 Tubulin.
BINDING 387 387 Tubulin.
MOD_RES 195 195 Phosphoserine.
MOD_RES 265 265 Phosphoserine.
MOD_RES 470 470 Phosphothreonine; by CDK1.
MOD_RES 481 481 Phosphothreonine; by CDK1.
MOD_RES 501 501 Phosphoserine.
MOD_RES 513 513 Phosphoserine.
MOD_RES 571 571 Phosphoserine.
MOD_RES 592 592 Phosphoserine.
MOD_RES 615 615 Phosphoserine.
MOD_RES 616 616 Phosphothreonine; by PLK1. |
Keyword | 3D-structure; Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 620 AA |
Protein Sequence | MRRSEVLAEE SIVCLQKALN HLREIWELIG IPEDQRLQRT EVVKKHIKEL LDMMIAEEES 60
LKERLIKSIS VCQKELNTLC SELHVEPFQE EGETTILQLE KDLRTQVELM RKQKKERKQE 120
LKLLQEQDQE LCEILCMPHY DIDSASVPSL EELNQFRQHV TTLRETKASR REEFVSIKRQ 180
IILCMEALDH TPDTSFERDV VCEDEDAFCL SLENIATLQK LLRQLEMQKS QNEAVCEGLR 240
TQIRELWDRL QIPEEEREAV ATIMSGSKAK VRKALQLEVD RLEELKMQNM KKVIEAIRVE 300
LVQYWDQCFY SQEQRQAFAP FCAEDYTESL LQLHDAEIVR LKNYYEVHKE LFEGVQKWEE 360
TWRLFLEFER KASDPNRFTN RGGNLLKEEK QRAKLQKFME YVAEQWEMHR LEKERAKQER 420
QLKNKKQTET EMLYGSAPRT PSKRRGLAPN TPGKARKLNT TTMSNATANS SIRPIFGGTV 480
YHSPVSRLPP SGSKPVAAST CSGKKTPRTG RHGANKENLE LNGSILSGGY PGSAPLQRNF 540
SINSVASTYS EFARELSKAS KSDATSGILN STNIQS 576 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |