UniProt Accession

 1433F_MOUSE; P68510; P11576; P70198; Q3TGZ9 

Genbank Protein ID

 U57311; D87661; AF077002; AB063572; AK077596; AK149224; AK168520; AK169035; AK169189; BC008187; BC061497 

Genbank Nucleotide ID

 AAC53256.1; BAA13422.1; AAC36290.1; BAB79599.1; BAC36887.1; BAE28768.1; BAE40399.1; BAE40826.1; BAE40965.1; AAH08187.1; AAH61497.1 

Protein Name

 14-3-3 protein eta 

Protein Synonyms/Alias

  

Gene Name

 Ywhah 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
50	NLLSVAYKNVVGARR	ubiquitination	[1]
69	VISSIEQKTMADGNE	acetylation	[2, 3]
69	VISSIEQKTMADGNE	ubiquitination	[1]
77	TMADGNEKKLEKVKA	ubiquitination	[1]
110	LLDKFLIKNCNDFQY	acetylation	[2]
110	LLDKFLIKNCNDFQY	ubiquitination	[1]
120	NDFQYESKVFYLKMK	acetylation	[2, 3]
120	NDFQYESKVFYLKMK	ubiquitination	[1]
125	ESKVFYLKMKGDYYR	ubiquitination	[1]
142	AEVASGEKKNSVVEA	ubiquitination	[1]
143	EVASGEKKNSVVEAS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylglycine (By similarity).
 MOD_RES 25 25 Phosphoserine (By similarity).
 MOD_RES 59 59 Phosphoserine.
 MOD_RES 117 117 Phosphotyrosine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0014704; C:intercalated disc; IC:BHF-UCL.
 GO:0003779; F:actin binding; IDA:ProtInc.
 GO:0035259; F:glucocorticoid receptor binding; ISS:UniProtKB.
 GO:0019904; F:protein domain specific binding; IDA:MGI.
 GO:0017080; F:sodium channel regulator activity; IDA:BHF-UCL.
 GO:0007010; P:cytoskeleton organization; NAS:ProtInc.
 GO:0006713; P:glucocorticoid catabolic process; ISS:UniProtKB.
 GO:0042921; P:glucocorticoid receptor signaling pathway; ISS:UniProtKB.
 GO:0006886; P:intracellular protein transport; IDA:MGI.
 GO:0043066; P:negative regulation of apoptotic process; NAS:ProtInc.
 GO:0050774; P:negative regulation of dendrite morphogenesis; IDA:MGI.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0007088; P:regulation of mitosis; NAS:ProtInc.
 GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IDA:BHF-UCL. 

Interpro

 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 

Pfam

 PF00244; 14-3-3 

SMART

 SM00101; 14_3_3 

PROSITE

 PS00796; 1433_1
 PS00797; 1433_2 

PRINTS

 PR00305; 1433ZETA.