UniProt Accession

 TTI2_HUMAN; Q6NXR4; D3DSV7; Q96IM2; Q9H5N4 

Genbank Protein ID

 AK026916; AC091144; CH471080; CH471080; BC007387; BC066935 

Genbank Nucleotide ID

 BAB15590.1; EAW63397.1; EAW63398.1; AAH07387.1; AAH66935.1 

Protein Name

 TELO2-interacting protein 2 

Protein Synonyms/Alias

  

Gene Name

 TTI2 

Gene Synonyms/Alias

 C8orf41 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	EARRGNVKDAVLKDL	ubiquitination	[1]
87	ETLGQVAKALEKYAA	ubiquitination	[1]
91	QVAKALEKYAAPSKE	ubiquitination	[1, 2]
97	EKYAAPSKEEEGGGD	ubiquitination	[1, 2]
112	GHSEAAEKAAQVGLL	ubiquitination	[1]
126	LFLKLLGKVETAKNS	ubiquitination	[1]
200	HGENEDEKGRLSVIL	ubiquitination	[1]
211	SVILGLLKPDLYKES	ubiquitination	[1]
220	DLYKESWKNNPAIKH	ubiquitination	[1]
329	LEKTLHWKGDGARPT	ubiquitination	[1]
474	RCSQGRVKGLLAKIP	ubiquitination	[1]
479	RVKGLLAKIPQSCED	ubiquitination	[1]
488	PQSCEDRKVVNYIRK	ubiquitination	[1]
495	KVVNYIRKVQQVSEG	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. 

Sequence Annotation

  

Keyword

 Complete proteome; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 508 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR018870; DUF2454. 

Pfam

 PF10521; DUF2454 

SMART

  

PROSITE

  

PRINTS