UniProt Accession

 PHKG2_HUMAN; P15735; A8K0C7; B4DEB7; E9PEU3; P11800 

Genbank Protein ID

 M31606; Y11950; Y11951; AK289492; AK293551; AC106886; BC002541; M14503 

Genbank Nucleotide ID

 AAA36442.1; CAA72694.1; CAA72694.1; BAF82181.1; BAG57028.1; AAH02541.1; AAA36518.1 

Protein Name

 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 

Protein Synonyms/Alias

 PHK-gamma-LT; PHK-gamma-T; PSK-C3; Phosphorylase kinase subunit gamma-2 

Gene Name

 PHKG2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
122	LFDYLTEKVALSEKE	ubiquitination	[1]
128	EKVALSEKETRSIMR	ubiquitination	[1]
155	NIVHRDLKPENILLD	ubiquitination	[2]
183	CHLEPGEKLRELCGT	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity). 

Sequence Annotation

 DOMAIN 24 291 Protein kinase.
 NP_BIND 30 38 ATP (By similarity).
 REGION 306 330 Calmodulin-binding (domain-N) (By
 REGION 346 370 Calmodulin-binding (domain-C) (By
 ACT_SITE 153 153 Proton acceptor (By similarity).
 BINDING 53 53 ATP (By similarity).  

Keyword

 3D-structure; Alternative splicing; ATP-binding; Calmodulin-binding; Carbohydrate metabolism; Complete proteome; Disease mutation; Glycogen metabolism; Glycogen storage disease; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005964; C:phosphorylase kinase complex; TAS:UniProtKB.
 GO:0005524; F:ATP binding; NAS:UniProtKB.
 GO:0004689; F:phosphorylase kinase activity; TAS:UniProtKB.
 GO:0050321; F:tau-protein kinase activity; TAS:UniProtKB.
 GO:0006006; P:glucose metabolic process; TAS:Reactome.
 GO:0005978; P:glycogen biosynthetic process; IEA:InterPro.
 GO:0005980; P:glycogen catabolic process; TAS:Reactome.
 GO:0045819; P:positive regulation of glycogen catabolic process; TAS:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
 IPR011009; Kinase-like_dom.
 IPR002291; Phosph_kin_gamma.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS

 PR01049; PHOSPHBKNASE.