UniProt Accession

 PMG1_YEAST; P00950; D6VX45; Q02117 

Genbank Protein ID

 X06408; X58789; Z26877; Z28152; S57976; BK006944 

Genbank Nucleotide ID

 CAA29698.1; CAA41595.1; CAA81501.1; CAA81994.1; AAB26026.1; DAA09011.1 

Protein Name

 Phosphoglycerate mutase 1 

Protein Synonyms/Alias

 PGAM 1; BPG-dependent PGAM 1; MPGM 1; Phosphoglyceromutase 1 

Gene Name

 GPM1 

Gene Synonyms/Alias

 GPM; YKL152C; YKL607 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
17	GQSEWNEKNLFTGWV	ubiquitination	[1]
27	FTGWVDVKLSAKGQQ	ubiquitination	[1]
31	VDVKLSAKGQQEAAR	ubiquitination	[1, 2]
44	ARAGELLKEKKVYPD	acetylation	[3]
44	ARAGELLKEKKVYPD	ubiquitination	[1]
47	GELLKEKKVYPDVLY	ubiquitination	[1]
57	PDVLYTSKLSRAIQT	acetylation	[3]
57	PDVLYTSKLSRAIQT	ubiquitination	[1, 2]
71	TANIALEKADRLWIP	acetylation	[3]
71	TANIALEKADRLWIP	ubiquitination	[1, 2]
96	HYGDLQGKDKAETLK	acetylation	[3]
98	GDLQGKDKAETLKKF	acetylation	[3]
109	LKKFGEEKFNTYRRS	acetylation	[3]
109	LKKFGEEKFNTYRRS	ubiquitination	[1, 2]
133	ASSPFSQKGDERYKY	acetylation	[3]
133	ASSPFSQKGDERYKY	ubiquitination	[1]
139	QKGDERYKYVDPNVL	ubiquitination	[1, 2]
169	YWQDVIAKDLLSGKT	acetylation	[3]
169	YWQDVIAKDLLSGKT	ubiquitination	[1]
175	AKDLLSGKTVMIAAH	acetylation	[3]
175	AKDLLSGKTVMIAAH	ubiquitination	[1, 2]
191	NSLRGLVKHLEGISD	acetylation	[3]
191	NSLRGLVKHLEGISD	ubiquitination	[1, 2]
221	FELDENLKPSKPSYY	acetylation	[3]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [3] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also Catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity. 

Sequence Annotation

 REGION 21 22 2-phospho-D-glycerate binding.
 REGION 87 90 2-phospho-D-glycerate binding.
 REGION 114 115 2-phospho-D-glycerate bindingy (By
 ACT_SITE 9 9 Tele-phosphohistidine intermediate.
 ACT_SITE 182 182
 BINDING 15 15 2-phospho-D-glycerate.
 BINDING 60 60 2-phospho-D-glycerate.
 MOD_RES 12 12 Phosphoserine.
 MOD_RES 49 49 Phosphotyrosine.
 MOD_RES 116 116 Phosphoserine.
 MOD_RES 127 127 Phosphoserine.
 MOD_RES 128 128 Phosphoserine.
 MOD_RES 185 185 Phosphoserine.
 MOD_RES 197 197 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Glycolysis; Isomerase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 247 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005758; C:mitochondrial intermembrane space; IDA:SGD.
 GO:0004619; F:phosphoglycerate mutase activity; IDA:SGD.
 GO:0006094; P:gluconeogenesis; IMP:SGD.
 GO:0006096; P:glycolysis; IMP:SGD. 

Interpro

 IPR013078; His_Pase_superF_clade-1.
 IPR001345; PG/BPGM_mutase_AS.
 IPR005952; Phosphogly_mut1. 

Pfam

 PF00300; His_Phos_1 

SMART

 SM00855; PGAM 

PROSITE

 PS00175; PG_MUTASE 

PRINTS