UniProt Accession

 TPIS_PLAF7; Q7KQM0 

Genbank Protein ID

 AE014187 

Genbank Nucleotide ID

 AAN36991.1 

Protein Name

 Triosephosphate isomerase 

Protein Synonyms/Alias

 TIM; Triose-phosphate isomerase 

Gene Name

 TPI 

Gene Synonyms/Alias

 PF14_0378 

Created Date

 July 27, 2013 

Organism

 Plasmodium falciparum (isolate 3D7) 

NCBI Taxa ID

 36329 

Lysine Modification

Position	Peptide	Type	References
100	IGHFERRKYFHETDE	acetylation	[1]

Reference

 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 

Functional Description

  

Sequence Annotation

 ACT_SITE 95 95 Electrophile (By similarity).
 ACT_SITE 165 165 Proton acceptor (By similarity).
 BINDING 10 10 Substrate (By similarity).
 BINDING 12 12 Substrate (By similarity).  

Keyword

 Complete proteome; Gluconeogenesis; Glycolysis; Isomerase; Pentose shunt; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 248 AA 

Protein Sequence

Gene Ontology

 GO:0004807; F:triose-phosphate isomerase activity; IEA:EC.
 GO:0006633; P:fatty acid biosynthetic process; ISS:GeneDB_Pfalciparum.
 GO:0006094; P:gluconeogenesis; ISS:GeneDB_Pfalciparum.
 GO:0006096; P:glycolysis; ISS:GeneDB_Pfalciparum.
 GO:0006098; P:pentose-phosphate shunt; ISS:GeneDB_Pfalciparum. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR022896; TrioseP_Isoase_bac/euk.
 IPR000652; Triosephosphate_isomerase.
 IPR020861; Triosephosphate_isomerase_AS. 

Pfam

 PF00121; TIM 

SMART

  

PROSITE

 PS00171; TIM_1
 PS51440; TIM_2 

PRINTS