| Tag | Content |
|---|
| CPLM ID | CPLM-012589 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TATA box-binding protein-associated factor RNA polymerase I subunit C |
Protein Synonyms/Alias | RNA polymerase I-specific TBP-associated factor 110 kDa; TAFI110; TATA box-binding protein-associated factor 1C; TBP-associated factor 1C; Transcription initiation factor SL1/TIF-IB subunit C |
Gene Name | TAF1C |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 191 | DNPQFLGKPGRIQLQ | ubiquitination | [1] | | 458 | AFPLLEPKIQWRLQE | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. |
Sequence Annotation | MOD_RES 848 848 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 869 AA |
Protein Sequence | MLPPLIDPWD PGLTARDLLF RGGCRYRKRP RVVLDVTEQI SRFLLDHGDV AFAPLGKLML 60
ENFKLEGAGS RTKKKTVVSV KKLLQDLGGH QPWGCPWAYL SNRQRRFSIL GGPILGTSVA 120
SHLAELLHEE LVLRWEQLLL DEACTGGALA WVPGRTPQFG QLVYPAGGAQ DRLHFQEVVL 180
TPGDNPQFLG KPGRIQLQGP VRQVVTCTVQ GETLLAVRSD YHCAVWKFGK QWQPTLLQAM 240
QVEKGATGIS LSPHLPGELA ICSRSGAVCL WSPEDGLRQI YRDPETLVFR DSSSWRWADF 300
TAHPRVLTVG DRTGVKMLDT QGPPGCGLLL FRLGAEASCQ KGERVLLTQY LGHSSPKCLP 360
PTLHLVCTQF SLYLVDERLP LVPMLKWNHG LPSPLLLARL LPPPRPSCVQ PLLLGGQGGQ 420
LQLLHLAEGA SVPRLAGPPQ SLPSRIDSLP AFPLLEPKIQ WRLQERLKAP TIGLAAVVPP 480
LPSAPTPGLV LFQLSAAGDV FYQQLRPQVD SSLRRDAGPP GDTQPDCHAP TASWTSQDTA 540
GCSQWLKALL KVPLAPPVWT APTFTHRQML GSTELRREEE EGQRLGVLRK AMARGQLLLQ 600
RDLGSLPAAE PPPAPESGLE DKLSERLGEA WAGRGAAWWE RQQGRTSEPG RQTRRPKRRT 660
QLSSSFSLSG HVDPSEDTSS PHSPEWPPAD ALPLPPTTPP SQELTPDACA QGVPSEQRQM 720
LRDYMAKLPP QRDTPGCATT PPHSQASSVR ATRSQQHTPV LSSSQPLRKK PRMGF 775 |
Gene Ontology | GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006363; P:termination of RNA polymerase I transcription; TAS:Reactome. GO:0006362; P:transcription elongation from RNA polymerase I promoter; TAS:Reactome. GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. GO:0006361; P:transcription initiation from RNA polymerase I promoter; TAS:Reactome. |
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