CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030657
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Annexin 
Protein Synonyms/Alias
  
Gene Name
 ANXA4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18QELRRAMKGAGTDEGubiquitination[1]
102DLYEAGEKKWGTDEVubiquitination[2]
211HFKRLYGKSLYSFIKubiquitination[3]
218KSLYSFIKGDTSGDYacetylation[4]
Reference
 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 237 AA 
Protein Sequence
MMTPTVLYDV QELRRAMKGA GTDEGCLIEI LASRTPEEIR RISQTYQQQY GRSLEDDIRS 60
DTSFMFQRVL VSLSAGGRDE GNYLDDALVR QDAQDLYEAG EKKWGTDEVK FLTVLCSRNR 120
NHLLHVFDEY KRISQKDIEQ SIKSETSGSF EDALLAIVKC MRNKSAYFAE KLYKSMKGLG 180
TDDNTLIRVM VSRAEIDMLD IRAHFKRLYG KSLYSFIKGD TSGDYRKVLL VLCGGDD 237 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0050819; P:negative regulation of coagulation; IEA:InterPro. 
Interpro
 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002391; AnnexinIV.
 IPR002392; AnnexinV. 
Pfam
 PF00191; Annexin 
SMART
 SM00335; ANX 
PROSITE
 PS00223; ANNEXIN 
PRINTS
 PR00196; ANNEXIN.
 PR00201; ANNEXINV.