| Tag | Content |
|---|
| CPLM ID | CPLM-003319 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Chaperone SurA |
Protein Synonyms/Alias | Peptidyl-prolyl cis-trans isomerase SurA; PPIase SurA; Rotamase SurA; Survival protein A |
Gene Name | surA |
Gene Synonyms/Alias | b0053; JW0052 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 293 | HARHILLKPSPIMTD | acetylation | [1] | | 306 | TDEQARVKLEQIAAD | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Chaperone involved in the correct folding and assembly of outer membrane proteins, such as OmpA, OmpF and LamB. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. Essential for the survival of E.coli in stationary phase. Required for pilus biogenesis. |
Sequence Annotation | DOMAIN 171 272 PpiC 1.
DOMAIN 282 382 PpiC 2. |
Keyword | 3D-structure; Chaperone; Complete proteome; Direct protein sequencing; Isomerase; Periplasm; Reference proteome; Repeat; Rotamase; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 428 AA |
Protein Sequence | MKNWKTLLLG IAMIANTSFA APQVVDKVAA VVNNGVVLES DVDGLMQSVK LNAAQARQQL 60
PDDATLRHQI MERLIMDQII LQMGQKMGVK ISDEQLDQAI ANIAKQNNMT LDQMRSRLAY 120
DGLNYNTYRN QIRKEMIISE VRNNEVRRRI TILPQEVESL AQQVGNQNDA STELNLSHIL 180
IPLPENPTSD QVNEAESQAR AIVDQARNGA DFGKLAIAHS ADQQALNGGQ MGWGRIQELP 240
GIFAQALSTA KKGDIVGPIR SGVGFHILKV NDLRGESKNI SVTEVHARHI LLKPSPIMTD 300
EQARVKLEQI AADIKSGKTT FAAAAKEFSQ DPGSANQGGD LGWATPDIFD PAFRDALTRL 360
NKGQMSAPVH SSFGWHLIEL LDTRNVDKTD AAQKDRAYRM LMNRKFSEEA ASWMQEQRAS 420
AYVKILSN 428 |
Gene Ontology | GO:0030288; C:outer membrane-bounded periplasmic space; IDA:EcoliWiki. GO:0042277; F:peptide binding; IDA:EcoCyc. GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IDA:EcoCyc. GO:0042710; P:biofilm formation; IMP:EcoCyc. GO:0051085; P:chaperone mediated protein folding requiring cofactor; IMP:EcoCyc. GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IMP:EcoliWiki. GO:0060274; P:maintenance of stationary phase; IMP:EcoliWiki. GO:0050821; P:protein stabilization; IDA:EcoCyc. |
Interpro | |
Pfam | |
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PROSITE | |
PRINTS | |