CPLM-024695

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-024695

UniProt Accession

GPHRA_HUMAN; B7ZAQ6; A6NN37; B2RUV3; B3KMN3; B4DXE7; Q53FQ9; Q5T2V8; Q5T5P5; Q659E2; Q6NVY5; Q9P0S4; Q9Y302

Genbank Protein ID

AF132947; AY358966; AB097024; AB097025; BT006679; AK021758; AK301939; AK316371; AK223223; AL390725; BX511042; CR628408; BX511042; AL390725; CR628408; CR628408; AL390725; BX511042; BC003187; BC067816; BC146880

Genbank Nucleotide ID

AAD27722.1; AAQ89325.1; BAC77377.1; BAC77378.1; AAP35325.1; BAG51045.1; BAG63359.1; BAH14742.1; BAD96943.1; CAI13712.2; CAI13712.2; CAI13712.2; CAI13224.2; CAI13224.2; CAI13224.2; CAM28366.1; CAM28366.1; CAM28366.1; AAH03187.1; AAH67816.1; AAI46881.1

Protein Name

Golgi pH regulator A

Protein Synonyms/Alias

Protein GPR89A; Putative MAPK-activating protein PM01; Putative NF-kappa-B-activating protein 90

Gene Name

GPR89A

Gene Synonyms/Alias

GPHRA; GPR89; SH120; CGI-13; UNQ192/PRO218

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
204	MDMIISKKKRMAMAR	ubiquitination	[1]
217	ARRTMFQKGEVHNKP	ubiquitination	[1]
223	QKGEVHNKPSGFWGM	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (By similarity).

Sequence Annotation

CARBOHYD 180 180 N-linked (GlcNAc...) (Potential).
CARBOHYD 243 243 N-linked (GlcNAc...) (Potential).

Keyword

Alternative splicing; Complete proteome; Glycoprotein; Golgi apparatus; Ion channel; Ion transport; Membrane; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

455 AA

Protein Sequence

MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEIRQYVV QVIFSVTFAF SCTMFELIIF 60
EILGVLNSSS RYFHWKMNLC VILLILVFMV PFYIGYFIVS NIRLLHKQRL LFSCLLWLTF 120
MYFFWKLGDP FPILSPKHGI LSIEQLISRV GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN 180
VTDTDILALE RRLLQTMDMI ISKKKRMAMA RRTMFQKGEV HNKPSGFWGM IKSVTTSASG 240
SENLTLIQQE VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK 300
IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI IIVTSIRGLL 360
ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM SMPLEYRTII TEVLGELQFN 420
FYHRWFDVIF LVSALSSILF LYLAHKQAPE KQMAP 455

Gene Ontology

GO:0032580; C:Golgi cisterna membrane; IDA:UniProtKB.
GO:0030660; C:Golgi-associated vesicle membrane; IDA:UniProtKB.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004871; F:signal transducer activity; IMP:UniProtKB.
GO:0008308; F:voltage-gated anion channel activity; IDA:UniProtKB.
GO:0051452; P:intracellular pH reduction; IDA:UniProtKB.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.

Interpro

IPR025969; ABA_GPCR_dom.
IPR022535; Golgi_pH-regulator_cons_dom.
IPR015672; GPCR89-rel.

Pfam

PF12430; ABA_GPCR
PF12537; DUF3735

SMART

PROSITE

PRINTS