| Tag | Content |
|---|
| CPLM ID | CPLM-020059 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Calsyntenin-3 |
Protein Synonyms/Alias | Alcadein-beta; Alc-beta |
Gene Name | CLSTN3 |
Gene Synonyms/Alias | CS3; KIAA0726 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 563 | RDFESLGKGMKVHVN | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May modulate calcium-mediated postsynaptic signals (By similarity). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (By similarity). |
Sequence Annotation | DOMAIN 29 145 Cadherin 1.
DOMAIN 146 246 Cadherin 2.
CARBOHYD 299 299 N-linked (GlcNAc...) (Potential).
CARBOHYD 327 327 N-linked (GlcNAc...) (Potential).
CARBOHYD 347 347 N-linked (GlcNAc...) (Potential).
CARBOHYD 507 507 N-linked (GlcNAc...) (Potential).
CARBOHYD 740 740 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Calcium; Cell adhesion; Cell membrane; Complete proteome; Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 956 AA |
Protein Sequence | MTLLLLPLLL ASLLASCSCN KANKHKPWIE AEYQGIVMEN DNTVLLNPPL FALDKDAPLR 60
YAGEICGFRL HGSGVPFEAV ILDKATGEGL IRAKEPVDCE AQKEHTFTIQ AYDCGEGPDG 120
ANTKKSHKAT VHVRVNDVNE FAPVFVERLY RAAVTEGKLY DRILRVEAID GDCSPQYSQI 180
CYYEILTPNT PFLIDNDGNI ENTEKLQYSG ERLYKFTVTA YDCGKKRAAD DAEVEIQVKP 240
TCKPSWQGWN KRIEYAPGAG SLALFPGIRL ETCDEPLWNI QATIELQTSH VAKGCDRDNY 300
SERALRKLCG AATGEVDLLP MPGPNANWTA GLSVHYSQDS SLIYWFNGTQ AVQVPLGGPS 360
GLGSGPQDSL SDHFTLSFWM KHGVTPNKGK KEEETIVCNT VQNEDGFSHY SLTVHGCRIA 420
FLYWPLLESA RPVKFLWKLE QVCDDEWHHY ALNLEFPTVT LYTDGISFDP ALIHDNGLIH 480
PPRREPALMI GACWTEEKNK EKEKGDNSTD TTQGDPLSIH HYFHGYLAGF SVRSGRLESR 540
EVIECLYACR EGLDYRDFES LGKGMKVHVN PSQSLLTLEG DDVETFNHAL QHVAYMNTLR 600
FATPGVRPLR LTTAVKCFSE ESCVSIPEVE GYVVVLQPDA PQILLSGTAH FARPAVDFEG 660
TNGVPLFPDL QITCSISHQV EAKKDESWQG TVTDTRMSDE IVHNLDGCEI SLVGDDLDPE 720
RESLLLDTTS LQQRGLELTN TSAYLTIAGV ESITVYEEIL RQARYRLRHG AALYTRKFRL 780
SCSEMNGRYS SNEFIVEVNV LHSMNRVAHP SHVLSSQQFL HRGHQPPPEM AGHSLASSHR 840
NSMIPSAATL IIVVCVGFLV LMVVLGLVRI HSLHRRVSGA GGPPGASSDP KDPDLFWDDS 900
ALTIIVNPME SYQNRQSCVT GAVGGQQEDE DSSDSEVADS PSSDERRIIE TPPHRY 956 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0045211; C:postsynaptic membrane; IEA:Compara. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0007156; P:homophilic cell adhesion; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |