UniProt Accession

 MDFI_HUMAN; Q99750 

Genbank Protein ID

 U78313; AL035588; BC007836 

Genbank Nucleotide ID

 AAB39748.1; CAB54148.1; AAH07836.1 

Protein Name

 MyoD family inhibitor 

Protein Synonyms/Alias

 Myogenic repressor I-mf 

Gene Name

 MDFI 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
143	LASQGSKKSKSSSKS	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Developmental protein; Differentiation; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0007257; P:activation of JUN kinase activity; IEA:Compara.
 GO:0042994; P:cytoplasmic sequestering of transcription factor; TAS:ProtInc.
 GO:0009950; P:dorsal/ventral axis specification; ISS:UniProtKB.
 GO:0009790; P:embryo development; TAS:ProtInc.
 GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Compara.
 GO:0043392; P:negative regulation of DNA binding; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; ISS:UniProtKB.
 GO:0060707; P:trophoblast giant cell differentiation; IEA:Compara. 

Interpro

 IPR026134; MDFI/MDFIC. 

Pfam

  

SMART

  

PROSITE

  

PRINTS