UniProt Accession

 IAH1_MOUSE; Q9DB29 

Genbank Protein ID

 AK005287; BC060949; BC087901 

Genbank Nucleotide ID

 BAB23934.1; AAH60949.1; AAH87901.1 

Protein Name

 Isoamyl acetate-hydrolyzing esterase 1 homolog 

Protein Synonyms/Alias

  

Gene Name

 Iah1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
63	GYNTRWAKIILPRLI	acetylation	[1, 2]
63	GYNTRWAKIILPRLI	succinylation	[2]
94	GANDSSLKDENPKQH	ubiquitination	[3]
99	SLKDENPKQHVPLDE	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Probable lipase (By similarity). 

Sequence Annotation

 ACT_SITE 24 24 Nucleophile (By similarity).
 ACT_SITE 197 197 By similarity.
 ACT_SITE 200 200 By similarity.
 BINDING 56 56 Substrate; via amide nitrogen (By
 BINDING 89 89 Substrate (By similarity).  

Keyword

 Complete proteome; Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 249 AA 

Protein Sequence

Gene Ontology

 GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR001087; Lipase_GDSL.
 IPR013831; SGNH_hydro-type_esterase_dom. 

Pfam

 PF00657; Lipase_GDSL 

SMART

  

PROSITE

 PS01098; LIPASE_GDSL_SER 

PRINTS