CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013363
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centromere/kinetochore protein zw10 homolog 
Protein Synonyms/Alias
  
Gene Name
 Zw10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
775RRAAALAKIK*****acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (By similarity). 
Sequence Annotation
 REGION 2 316 Interaction with RINT1 (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 775 775 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Endoplasmic reticulum; ER-Golgi transport; Kinetochore; Membrane; Mitosis; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 777 AA 
Protein Sequence
MASFVTEVLA HSGSLEKEDL GTRISRLTRR VEEIKGEVCN MISKKYSEFL PTMQSAQALV 60
TQVDTLSNDI DQLKSRIETE VCRDLHISTV EFTNLKQRLE RDSVVLNLLK QLQEFSSAIE 120
EYNSALAEKK YIPAARLLEE AQECLKLLKS KKCFDLKMLK SLSMELTVQK QNILYHLGED 180
WQKLVVWKFP PSKDTSSLES CLQTELHLCT EQPEKEMTPL PSISSVLLAF SILGELPTKL 240
KSFGQMLLKY ILKPLVTCPS LHAVIERQPN SVSICFQSLA TDSEHPPPPE AFAKIQLVLE 300
VLQKQLLDLP LDADLEIGKV PEIVLAEMLG EVIWEDLSDC LIRNCLVYSI PTNSSKLQQY 360
EEIIQSTEEF EKSLKEMRFL KGDTTDLLKY ARNINSHFAN KKCQDVIVAA RHLMTSEIHN 420
TVKIGPDCEE TLPDLPSPDA DHRLQVQVCK VQFTDAGNLE PETSLDPRSF SLPTCRISEA 480
VKKLMELAYQ TLLEATTSSD QCAVQLFYSV RNIFHLFHDV VPTYHKENLQ KLPQLAAIHH 540
NNCMYIAHHL LTLGHQFRSR LTPILCDGTT TFVDLVPGFR RLGTECFLAQ MRTQKGELLE 600
RLSSARSFAN MDDEENYSAA SKAVRQVLHQ LKRLGIVWQD VLPVNIYCKA MGTLLNTVIA 660
EMIGRITALE DISTEDGDRL YSLCKTVMDE GPQVFAPLSD ENKNKKYQEE VPVYVSKWMP 720
FKELMIMLQA SLQEIGDRWA DGKGPLATAF PSSEVKALIR ALFQNTERRA AALAKIK 777 
Gene Ontology
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; ISS:HGNC.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0000776; C:kinetochore; ISS:HGNC.
 GO:0005828; C:kinetochore microtubule; ISS:HGNC.
 GO:0005634; C:nucleus; ISS:HGNC.
 GO:0000922; C:spindle pole; ISS:HGNC.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; ISS:HGNC.
 GO:0000132; P:establishment of mitotic spindle orientation; IEA:Compara.
 GO:0007093; P:mitotic cell cycle checkpoint; ISS:HGNC.
 GO:0007080; P:mitotic metaphase plate congression; IEA:Compara.
 GO:0000070; P:mitotic sister chromatid segregation; ISS:HGNC.
 GO:0006461; P:protein complex assembly; ISS:HGNC.
 GO:0034501; P:protein localization to kinetochore; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007096; P:regulation of exit from mitosis; ISS:HGNC. 
Interpro
 IPR009361; RZZ-complex_Zw10. 
Pfam
 PF06248; Zw10 
SMART
  
PROSITE
  
PRINTS