| Tag | Content |
|---|
| CPLM ID | CPLM-013820 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Butyrophilin subfamily 2 member A2 |
Protein Synonyms/Alias | |
Gene Name | BTN2A2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
NCBI Taxa ID | 9601 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 102 | GRTTFVSKDISRGSV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). |
Sequence Annotation | DOMAIN 31 142 Ig-like V-type.
DOMAIN 150 232 Ig-like C2-type.
DOMAIN 311 507 B30.2/SPRY.
CARBOHYD 47 47 N-linked (GlcNAc...) (Potential).
CARBOHYD 115 115 N-linked (GlcNAc...) (Potential).
CARBOHYD 121 121 N-linked (GlcNAc...) (Potential).
DISULFID 52 126 By similarity. |
Keyword | Coiled coil; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 528 AA |
Protein Sequence | MESAAALHFS RPASLLLLLL LSLCALVSAQ VTVVGPTDPI LGMVGENTTL RCHLSPEKNA 60
EDMEVRWFRS QFSPAVFVYK GGRERTEEQM EEYRGRTTFV SKDISRGSVA LVIHNITAQE 120
NGTYRCYFQE GRSYDEAILH LIVAGLGSKP LIEMRGHEDG GIRLECISRG WYPKPLTVWR 180
DPYGGVVPAL KEVSMPDADS LFMVTTAVII RDKSVRNMFC SINNTLLSQK KESVIFIPES 240
FMPSVSPCAV ALPIVVVILM ILFAVCMYWI NKLQKEKKIL SGEKEFERET REIAVKELEK 300
ERVQKEEELQ VKEKLQEELR WRRTFLHAVD VVLDPDTAHP DLFLSEDRRS VRRRPFRHLG 360
ESMPDNPERF NSQPCVLGRE SFASGKHYWE VEVENVIEWT VGVCRDSVER KGEVLLIPQN 420
GFWTLEMHKS QYRAVSSPDR IIPLKESLCR VGVFLDYEAG DVSFYNMRDR SHIYTCPRSA 480
FSVPVRPFFR LGCEDSPIFI CPALTGANGV TVPEEGLTLH RVGTHQSL 528 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0046007; P:negative regulation of activated T cell proliferation; ISS:UniProtKB. GO:0031324; P:negative regulation of cellular metabolic process; ISS:UniProtKB. GO:0050710; P:negative regulation of cytokine secretion; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |