| Tag | Content |
|---|
| CPLM ID | CPLM-008135 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | POU domain, class 3, transcription factor 4 |
Protein Synonyms/Alias | Brain-specific homeobox/POU domain protein 4; Brain-4; Brn-4; Octamer-binding protein 9; Oct-9; Octamer-binding transcription factor 9; OTF-9 |
Gene Name | POU3F4 |
Gene Synonyms/Alias | BRN4; OTF9 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 353 | EVYSHTVKTDTSCHD | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain. |
Sequence Annotation | DOMAIN 186 260 POU-specific.
DNA_BIND 278 337 Homeobox. |
Keyword | Complete proteome; Deafness; Disease mutation; DNA-binding; Homeobox; Non-syndromic deafness; Nucleus; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 361 AA |
Protein Sequence | MATAASNPYS ILSSTSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG HPLGHHWVTS 60
LSDGGPWSST LATSPLDQQD VKPGREDLQL GAIIHHRSPH VAHHSPHTNH PNAWGASPAP 120
NPSITSSGQP LNVYSQPGFT VSGMLEHGGL TPPPAAASAQ SLHPVLREPP DHGELGSHHC 180
QDHSDEETPT SDELEQFAKQ FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEGLQL 240
SFKNMCKLKP LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC 300
PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH TVKTDTSCHD 360
L 361 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003680; F:AT DNA binding; IEA:Compara. GO:0003690; F:double-stranded DNA binding; IEA:Compara. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0090103; P:cochlea morphogenesis; ISS:UniProtKB. GO:0021879; P:forebrain neuron differentiation; IEA:Compara. GO:2001054; P:negative regulation of mesenchymal cell apoptotic process; ISS:UniProtKB. GO:0007605; P:sensory perception of sound; TAS:ProtInc. GO:0006366; P:transcription from RNA polymerase II promoter; IEA:Compara. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |