CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037205
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mitogen-activated protein kinase kinase kinase 15 
Protein Synonyms/Alias
  
Gene Name
 MAP3K15 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
583PMKEPTIKFYTKQILmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1145 AA 
Protein Sequence
MVTQKNTASS GNYYFIPYIV TPCADYFCCE SDAQRRASEY MQPNWDNILG PLCMPLVDRF 60
ISLLKDIHVT SCVYYKETLL NDIRKAREKY QGEELAKELA RIKLRMDNTE VLTSDIIINL 120
LLSYRDIQDY DAMVKLVETL EMLPTCDLAD QHNIKFHYAF ALNRRNSTGD REKALQIMLQ 180
VLQSCDHPGP DMFCLCGRIY KDIFLDSDCK DDTSRDSAIE WYRKGFELQS SLYSGINLAV 240
LLIVAGQQFE TSLELRKIGV RLNSLLGRKG SLEKMNNYWD VGQFFSVSML AHDVGKAVQA 300
AERLFKLKPP VWYLRSLVQN LLLIRRFKKT IIEHSPRQER LNFWLDIIFE ATNEVTNGLR 360
FPVLVIEPTK VYQPSYVSIN NEAEERTVSL WHVSPTEMKQ MHEWNFTASS IKGISLSKFD 420
ERCCFLYVHD NSDDFQIYFS TEEQCSRFFS LVKEMITNTA GSTVELEGET DGDTLEYEYD 480
HDANGERVVL GKGTYGIVYA GRDLSNQVRI AIKEIPERDS RYSQPLHEEI ALHKYLKHRN 540
IVQYLGSVSE NGYIKIFMEQ VPGGSLSALL RSKWGPMKEP TIKFYTKQIL EGLKYLHENQ 600
IVHRDIKGDN VLVNTYSGVV KISDFGTSKR LAGVNPCTET FTGTLQYMAP EIIDQGPRGY 660
GAPADIWSLG CTIIEMATSK PPFHELGEPQ AAMFKVGMFK IHPEIPEALS AEARAFILSC 720
FEPDPHKRAT TAELLREGFL RQVNKGKKNR IAFKPSEGPR GVVLALPTQG EPMATSSSEH 780
GSVSPDSDAQ PDALFERTRA PRHHLGHLLS VPDESSALED RGLASSPEDR DQGLFLLRKD 840
SERRAILYKI LWEEQNQVAS NLQECVAQSS EELHLSVGHI KQIIGILRDF IRSPEHRVMA 900
TTISKLKVDL DFDSSSISQI HLVLFGFQDA VNKILRNHLI RPHWMFAMDN IIRRAVQAAV 960
TILIPELRAH FEPTCETEGV DKDMDEAEEG YPPATGPGQE AQPHQQHLSL QLGELRQETN 1020
RLLEHLVEKE REYQNLLRQT LEQKTQELYH LQLKLKSNCI TENPAGPYGQ RTDKELIDWL 1080
RLQGADAKTI EKIVEEGYTL SDILNEITKE DLRYLRLRGG LLCRLWSAVS QYRRAQEASE 1140
TKDKA 1145 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR025136; DUF4071.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR013761; SAM/pointed.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF13281; DUF4071
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS