UniProt Accession

 S1PR1_HUMAN; P21453; D3DT66; Q9BYY4; Q9NYN8 

Genbank Protein ID

 M31210; AF022137; AF233365; AK312493; CR541786; CR542269; AL109741; CH471097; CH471097; BC018650 

Genbank Nucleotide ID

 AAA52336.1; AAC51905.1; AAF43420.1; BAG35395.1; CAG46585.1; CAG47065.1; CAI21861.1; EAW72927.1; EAW72928.1; AAH18650.1 

Protein Name

 Sphingosine 1-phosphate receptor 1 

Protein Synonyms/Alias

 S1P receptor 1; S1P1; Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD363 

Gene Name

 S1PR1 

Gene Synonyms/Alias

 CHEDG1; EDG1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
341	GDSAGKFKRPIIAGM	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins. 

Sequence Annotation

 MOD_RES 236 236 Phosphothreonine; by PKB/AKT1.
 MOD_RES 353 353 Phosphoserine (Potential).
 LIPID 328 328 S-palmitoyl cysteine (By similarity).
 CARBOHYD 30 30 N-linked (GlcNAc...) (Potential).
 CARBOHYD 36 36 N-linked (GlcNAc...) (Potential).  

Keyword

 3D-structure; Cell membrane; Complete proteome; G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 382 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc.
 GO:0046625; F:sphingolipid binding; IEA:Compara.
 GO:0038036; F:sphingosine-1-phosphate receptor activity; IEA:InterPro.
 GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0051482; P:elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; IEA:Compara.
 GO:0045446; P:endothelial cell differentiation; IEA:Compara.
 GO:0051497; P:negative regulation of stress fiber assembly; IEA:Compara.
 GO:0030182; P:neuron differentiation; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0050927; P:positive regulation of positive chemotaxis; IEA:Compara.
 GO:0032320; P:positive regulation of Ras GTPase activity; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0030155; P:regulation of cell adhesion; IEA:Compara.
 GO:0003376; P:sphingosine-1-phosphate signaling pathway; IEA:GOC.
 GO:0019226; P:transmission of nerve impulse; IEA:Compara. 

Interpro

 IPR000987; EDG1_rcpt.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM.
 IPR004061; S1P_rcpt. 

Pfam

 PF00001; 7tm_1 

SMART

  

PROSITE

 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 

PRINTS

 PR00642; EDG1RECEPTOR.
 PR00237; GPCRRHODOPSN.
 PR01523; S1PRECEPTOR.