CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003829
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fasciclin-1 
Protein Synonyms/Alias
 Fasciclin I; FAS I; FCN 
Gene Name
 Fas1 
Gene Synonyms/Alias
 CG6588 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
164PNNPNALKFLKNAEEacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
 Neural cell adhesion molecule. 
Sequence Annotation
 DOMAIN 22 144 FAS1 1.
 DOMAIN 166 310 FAS1 2.
 DOMAIN 317 463 FAS1 3.
 DOMAIN 467 616 FAS1 4.
 LIPID 625 625 GPI-anchor amidated alanine (Potential).
 CARBOHYD 47 47 N-linked (GlcNAc...) (Potential).
 CARBOHYD 368 368 N-linked (GlcNAc...) (Potential).
 CARBOHYD 416 416 N-linked (GlcNAc...) (Potential).
 CARBOHYD 441 441 N-linked (GlcNAc...).
 CARBOHYD 493 493 N-linked (GlcNAc...); atypical.
 CARBOHYD 497 497 N-linked (GlcNAc...).  
Keyword
 3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Reference proteome; Repeat; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 652 AA 
Protein Sequence
MLNAAALLLA LLCAANAAAA ADLADKLRDD SELSQFYSLL ESNQIANSTL SLRSCTIFVP 60
TNEAFQRYKS KTAHVLYHIT TEAYTQKRLP NTVSSDMAGN PPLYITKNSN GDIFVNNARI 120
IPSLSVETNS DGKRQIMHII DEVLEPLTVK AGHSDTPNNP NALKFLKNAE EFNVDNIGVR 180
TYRSQVTMAK KESVYDAAGQ HTFLVPVDEG FKLSARSSLV DGKVIDGHVI PNTVIFTAAA 240
QHDDPKASAA FEDLLKVTVS FFKQKNGKMY VKSNTIVGDA KHRVGVVLAE IVKANIPVSN 300
GVVHLIHRPL MIIDTTVTQF LQSFKENAEN GALRKFYEVI MDNGGAVLDD INSLTEVTIL 360
APSNEAWNSS NINNVLRDRN KMRQILNMHI IKDRLNVDKI RQKNANLIAQ VPTVNNNTFL 420
YFNVRGEGSD TVITVEGGGV NATVIQADVA QTNGYVHIID HVLGVPYTTV LGKLESDPMM 480
SDTYKMGKFS HFNDQLNNTQ RRFTYFVPRD KGWQKTELDY PSAHKKLFMA DFSYHSKSIL 540
ERHLAISDKE YTMKDLVKFS QESGSVILPT FRDSLSIRVE EEAGRYVIIW NYKKINVYRP 600
DVECTNGIIH VIDYPLLEEK DVVVAGGSYL PESSICIILA NLIMITVAKF LN 652 
Gene Ontology
 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:FlyBase.
 GO:0050839; F:cell adhesion molecule binding; IDA:FlyBase.
 GO:0007411; P:axon guidance; IGI:FlyBase.
 GO:0016338; P:calcium-independent cell-cell adhesion; IDA:FlyBase.
 GO:0007156; P:homophilic cell adhesion; IDA:FlyBase.
 GO:0008038; P:neuron recognition; IDA:FlyBase. 
Interpro
 IPR000782; FAS1_domain. 
Pfam
 PF02469; Fasciclin 
SMART
 SM00554; FAS1 
PROSITE
 PS50213; FAS1 
PRINTS