CPLM-020341

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-020341

UniProt Accession

FACD2_HUMAN; Q9BXW9; Q2LA86; Q69YP9; Q6PJN7; Q9BQ06; Q9H9T9

Genbank Protein ID

AF230336; AF273251; AF273222; AF273223; AF273227; AF273231; AF273235; AF273243; AF273241; AF273239; AF273245; AF273246; AF273247; AF273248; AF273249; AF273250; AF273236; AF273237; AF273238; AF273224; AF273226; AF273228; AF273230; AF273232; AF273234; AF273240; AF273242; AF273244; AF273233; AF273229; AF273225; AF273251; AF273222; AF273223; AF273224; AF273225; AF273226; AF273227; AF273228; AF273229; AF273230; AF273231; AF273232; AF273233; AF273234; AF273235; AF273236; AF273237; AF273238; AF273239; AF273240; AF273241; AF273242; AF273243; AF273244; AF273245; AF273246; AF273247; AF273248; AF273249; AF273250; AF340183; DQ341263; BC013582; AK022613; AL832427

Genbank Nucleotide ID

AAL05980.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18772.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK18773.1; AAK15369.1; ABC67466.1; AAH13582.1; BAB14132.1; CAH10647.1

Protein Name

Fanconi anemia group D2 protein

Protein Synonyms/Alias

Protein FACD2

Gene Name

FANCD2

Gene Synonyms/Alias

FACD

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
165	PEYFFENKNSDEINI	ubiquitination	[1]
561	DMHLVIRKQLSSTVF	ubiquitination	[1]
1216	PELINSPKDASSSTF	ubiquitination	[1]
1400	DLQGEEIKSQNSQES	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.

Sequence Annotation

REGION 1 291 Interaction with FANCE.
REGION 248 359 Interaction with BRCA2.
MOD_RES 8 8 Phosphoserine.
MOD_RES 222 222 Phosphoserine; by ATM.
MOD_RES 592 592 Phosphoserine.
MOD_RES 594 594 Phosphoserine.
MOD_RES 717 717 Phosphoserine.
MOD_RES 1401 1401 Phosphoserine; by ATM (Probable).
MOD_RES 1404 1404 Phosphoserine; by ATM.
MOD_RES 1412 1412 Phosphoserine.
CROSSLNK 561 561 Glycyl lysine isopeptide (Lys-Gly)

Keyword

Alternative splicing; Cell cycle; Complete proteome; Disease mutation; DNA damage; DNA repair; Fanconi anemia; Isopeptide bond; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1471 AA

Protein Sequence

MVSKRRLSKS EDKESLTEDA SKTRKQPLSK KTKKSHIANE VEENDSIFVK LLKISGIILK 60
TGESQNQLAV DQIAFQKKLF QTLRRHPSYP KIIEEFVSGL ESYIEDEDSF RNCLLSCERL 120
QDEEASMGAS YSKSLIKLLL GIDILQPAII KTLFEKLPEY FFENKNSDEI NIPRLIVSQL 180
KWLDRVVDGK DLTTKIMQLI SIAPENLQHD IITSLPEILG DSQHADVGKE LSDLLIENTS 240
LTVPILDVLS SLRLDPNFLL KVRQLVMDKL SSIRLEDLPV IIKFILHSVT AMDTLEVISE 300
LREKLDLQHC VLPSRLQASQ VKLKSKGRAS SSGNQESSGQ SCIILLFDVI KSAIRYEKTI 360
SEAWIKAIEN TASVSEHKVF DLVMLFIIYS TNTQTKKYID RVLRNKIRSG CIQEQLLQST 420
FSVHYLVLKD MCSSILSLAQ SLLHSLDQSI ISFGSLLYKY AFKFFDTYCQ QEVVGALVTH 480
ICSGNEAEVD TALDVLLELV VLNPSAMMMN AVFVKGILDY LDNISPQQIR KLFYVLSTLA 540
FSKQNEASSH IQDDMHLVIR KQLSSTVFKY KLIGIIGAVT MAGIMAADRS ESPSLTQERA 600
NLSDEQCTQV TSLLQLVHSC SEQSPQASAL YYDEFANLIQ HEKLDPKALE WVGHTICNDF 660
QDAFVVDSCV VPEGDFPFPV KALYGLEEYD TQDGIAINLL PLLFSQDFAK DGGPVTSQES 720
GQKLVSPLCL APYFRLLRLC VERQHNGNLE EIDGLLDCPI FLTDLEPGEK LESMSAKERS 780
FMCSLIFLTL NWFREIVNAF CQETSPEMKG KVLTRLKHIV ELQIILEKYL AVTPDYVPPL 840
GNFDVETLDI TPHTVTAISA KIRKKGKIER KQKTDGSKTS SSDTLSEEKN SECDPTPSHR 900
GQLNKEFTGK EEKTSLLLHN SHAFFRELDI EVFSILHCGL VTKFILDTEM HTEATEVVQL 960
GPPELLFLLE DLSQKLESML TPPIARRVPF LKNKGSRNIG FSHLQQRSAQ EIVHCVFQLL 1020
TPMCNHLENI HNYFQCLAAE NHGVVDGPGV KVQEYHIMSS CYQRLLQIFH GLFAWSGFSQ 1080
PENQNLLYSA LHVLSSRLKQ GEHSQPLEEL LSQSVHYLQN FHQSIPSFQC ALYLIRLLMV 1140
ILEKSTASAQ NKEKIASLAR QFLCRVWPSG DKEKSNISND QLHALLCIYL EHTESILKAI 1200
EEIAGVGVPE LINSPKDASS STFPTLTRHT FVVFFRVMMA ELEKTVKKIE PGTAADSQQI 1260
HEEKLLYWNM AVRDFSILIN LIKVFDSHPV LHVCLKYGRL FVEAFLKQCM PLLDFSFRKH 1320
REDVLSLLET FQLDTRLLHH LCGHSKIHQD TRLTQHVPLL KKTLELLVCR VKAMLTLNNC 1380
REAFWLGNLK NRDLQGEEIK SQNSQESTAD ESEDDMSSQA SKSKATEDGE EDEVSAGEKE 1440
QDSDESYDDS D 1451

Gene Ontology

GO:0000793; C:condensed chromosome; IEA:Compara.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0006281; P:DNA repair; TAS:Reactome.
GO:0007276; P:gamete generation; IEA:Compara.
GO:0010332; P:response to gamma radiation; IDA:UniProtKB.
GO:0007129; P:synapsis; IEA:Compara.

Interpro

Pfam

SMART

PROSITE

PRINTS