UniProt Accession

 BORG5_HUMAN; Q00587; A8K825; Q96GN1 

Genbank Protein ID

 M88338; CR456524; AK292190; AL022315; CH471095; BC009356 

Genbank Nucleotide ID

 AAA36606.1; CAG30410.1; BAF84879.1; CAB42833.1; EAW60164.1; AAH09356.1 

Protein Name

 Cdc42 effector protein 1 

Protein Synonyms/Alias

 Binder of Rho GTPases 5; Serum protein MSE55 

Gene Name

 CDC42EP1 

Gene Synonyms/Alias

 BORG5; CEP1; MSE55 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
30	WVSSSQGKRRLTADM	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. 

Sequence Annotation

 DOMAIN 38 52 CRIB.
 REPEAT 220 226 1.
 REPEAT 227 233 2.
 REPEAT 234 240 3.
 REPEAT 241 247 4.
 REPEAT 248 254 5.
 REPEAT 255 261 6.
 REPEAT 262 268 7.
 REPEAT 269 275 8.
 REGION 220 275 8 X 7 AA tandem repeats of [PT]-[AT]-A-
 MOD_RES 19 19 Phosphoserine.
 MOD_RES 101 101 Phosphoserine.
 MOD_RES 113 113 Phosphoserine.
 MOD_RES 121 121 Phosphoserine.
 MOD_RES 190 190 Phosphoserine.
 MOD_RES 192 192 Phosphoserine.
 MOD_RES 195 195 Phosphoserine.
 MOD_RES 350 350 Phosphoserine.
 MOD_RES 353 353 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 391 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IDA:HPA.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0031274; P:positive regulation of pseudopodium assembly; IDA:UniProtKB.
 GO:0008360; P:regulation of cell shape; IDA:UniProtKB.
 GO:0007266; P:Rho protein signal transduction; IEA:Compara. 

Interpro

 IPR000095; PAK_box_Rho-bd. 

Pfam

 PF00786; PBD 

SMART

 SM00285; PBD 

PROSITE

 PS50108; CRIB 

PRINTS