UniProt Accession

 HNMT_HUMAN; P50135; B2R9J3; Q546Z6; Q7Z7I2; Q8IU56; Q8WW98; Q9BRW6 

Genbank Protein ID

 D16224; U08092; U44111; U44106; U44107; U44108; U44109; U44110; AF523358; AF523359; AF523360; AF523356; AF523357; AK313804; AC093674; CH471058; CH471058; CH471058; BC005907; BC020677; AH012839 

Genbank Nucleotide ID

 BAA03752.1; AAA17423.1; AAB18137.1; AAB18137.1; AAB18137.1; AAB18137.1; AAB18137.1; AAB18137.1; AAN33016.1; AAN33017.1; AAN33018.1; AAN33014.1; AAN33015.1; BAG36540.1; AAY24212.1; EAX11612.1; EAX11613.1; EAX11614.1; AAH05907.1; AAH20677.1; AAP42155.1 

Protein Name

 Histamine N-methyltransferase 

Protein Synonyms/Alias

 HMT 

Gene Name

 HNMT 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
112	TSNLENVKFAWHKET	acetylation	[1]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. 

Sequence Annotation

 BINDING 28 28 Substrate.
 BINDING 60 60 S-adenosyl-L-methionine; via carbonyl
 BINDING 89 89 S-adenosyl-L-methionine.
 BINDING 94 94 S-adenosyl-L-methionine.
 BINDING 120 120 S-adenosyl-L-methionine; via amide
 BINDING 142 142 S-adenosyl-L-methionine; via carbonyl
 BINDING 283 283 Substrate.
 MOD_RES 3 3 Phosphoserine (By similarity).
 MOD_RES 10 10 Phosphoserine (By similarity).
 MOD_RES 18 18 Phosphoserine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Methyltransferase; Phosphoprotein; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 292 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0046539; F:histamine N-methyltransferase activity; IEA:EC.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0006972; P:hyperosmotic response; IEA:Compara.
 GO:0007585; P:respiratory gaseous exchange; TAS:ProtInc.
 GO:0014075; P:response to amine stimulus; IEA:Compara.
 GO:0042220; P:response to cocaine; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0070555; P:response to interleukin-1; IEA:Compara.
 GO:0002347; P:response to tumor cell; IEA:Compara. 

Interpro

 IPR016673; Histamine_N-methyltransferase. 

Pfam

  

SMART

  

PROSITE

  

PRINTS