CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017311
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 L-fucose kinase 
Protein Synonyms/Alias
 Fucokinase 
Gene Name
 FUK 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
464VPWSEFFKRTGVRAWubiquitination[1, 2, 3, 4]
907SRAQLPLKVEVEEVTubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides. 
Sequence Annotation
 NP_BIND 834 845 ATP (Potential).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1084 AA 
Protein Sequence
MEQPKGVDWT VIILTCQYKD SVQVFQRELE VRQKREQIPA GTLLLAVEDP EKRVGSGGAT 60
LNALLVAAEH LSARAGFTVV TSDVLHSAWI LILHMGRDFP FDDCGRAFTC LPVENPEAPV 120
EALVCNLDCL LDIMTYRLGP GSPPGVWVCS TDMLLSVPAN PGISWDSFRG ARVIALPGSP 180
AYAQNHGVYL TDPQGLVLDI YYQGTEAEIQ RCVRPDGRVP LVSGVVFFSV ETAERLLATH 240
VSPPLDACTY LGLDSGARPV QLSLFFDILH CMAENVTRED FLVGRPPELG QGDADVAGYL 300
QSARAQLWRE LRDQPLTMAY VSSGSYSYMT SSASEFLLSL TLPGAPGAQI VHSQVEEQQL 360
LAAGSSVVSC LLEGPVQLGP GSVLQHCHLQ GPIHIGAGCL VTGLDTAHSK ALHGRELRDL 420
VLQGHHTRLH GSPGHAFTLV GRLDSWERQG AGTYLNVPWS EFFKRTGVRA WDLWDPETLP 480
AEYCLPSARL FPVLHPSREL GPQDLLWMLD HQEDGGEALR AWRASWRLSW EQLQPCLDRA 540
ATLASRRDLF FRQALHKARH VLEARQDLSL RPLIWAAVRE GCPGPLLATL DQVAAGAGDP 600
GVAARALACV ADVLGCMAEG RGGLRSGPAA NPEWMRPFSY LECGDLAAGV EALAQERDKW 660
LSRPALLVRA ARHYEGAGQI LIRQAVMSAQ HFVSTEQVEL PGPGQWVVAE CPARVDFSGG 720
WSDTPPLAYE LGGAVLGLAV RVDGRRPIGA RARRIPEPEL WLAVGPRQDE MTVKIVCRCL 780
ADLRDYCQPH APGALLKAAF ICAGIVHVHS ELQLSEQLLR TFGGGFELHT WSELPHGSGL 840
GTSSILAGTA LAALQRAAGR VVGTEALIHA VLHLEQVLTT GGGWQDQVGG LMPGIKVGRS 900
RAQLPLKVEV EEVTVPEGFV QKLNDHLLLV YTGKTRLARN LLQDVLRSWY ARLPAVVQNA 960
HSLVRQTEEC AEGFRQGSLP LLGQCLTSYW EQKKLMAPGC EPLTVRRMMD VLAPHVHGQS 1020
LAGAGGGGFL YLLTKEPQQK EALEAVLAKT EGLGNYSIHL VEVDTQGLSL KLLGTEASTC 1080
CPFP 1084 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0050201; F:fucokinase activity; NAS:UniProtKB. 
Interpro
 IPR012887; Fucokinase.
 IPR013750; GHMP_kinase_C_dom.
 IPR006204; GHMP_kinase_N_dom.
 IPR006206; Mevalonate/galactokinase.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 
Pfam
 PF07959; Fucokinase
 PF08544; GHMP_kinases_C
 PF00288; GHMP_kinases_N 
SMART
  
PROSITE
 PS00627; GHMP_KINASES_ATP 
PRINTS
 PR00959; MEVGALKINASE.