CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006755
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription termination/antitermination protein NusA 
Protein Synonyms/Alias
  
Gene Name
 nusA 
Gene Synonyms/Alias
 STM3287 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
22EKALPREKIFEALESacetylation[1]
36SALATATKKKYEQEIacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Participates in both transcription termination and antitermination (By similarity). 
Sequence Annotation
 DOMAIN 135 205 S1 motif.
 DOMAIN 307 373 KH.
 REPEAT 369 419 1.
 REPEAT 444 494 2.
 REGION 369 494 2 X 51 AA approximate repeats.  
Keyword
 Complete proteome; Cytoplasm; Reference proteome; Repeat; RNA-binding; Transcription; Transcription antitermination; Transcription regulation; Transcription termination. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 500 AA 
Protein Sequence
MNKEILAVVE AVSNEKALPR EKIFEALESA LATATKKKYE QEIDVRVEID RKSGDFDTFR 60
RWLIVEEVTM PTKEITLEAA RFEDESLNVG DYVEDQIESV TFDRITTQTA KQVIVQKVRE 120
AERAMVVDQF RDQEGEIVTG VVKKVNRDNI SLEIKSEGMA GNAEAVILRE DMLPRENFRP 180
GDRIRGVLYA VRPEARGAQL FVTRSKPEML IELFRIEVPE IGEEVIEIKA AARDPGSRAK 240
IAVKTNDKRI DPVGACVGMR GARVQAVSTE LGGERIDIVL WDDNPAQFVI NAMAPADVAS 300
IVVDEDKHTM DIAVEAGNLA QAIGRNGQNV RLASQLSGWE LNVMTVDDLQ AKHQAEAHAA 360
IEIFTKYLDI DEEFATVLVE EGFSTLEELA YVPMKELLEI DGLDEPTVEA LRERAKNALA 420
TLAQDQEASL GDNKPADDLL NLEGLDRDMA FKLAARGVCT LEDLADQGID DLADIEGLTD 480
EKAGELIMAA RNICWFGDEA 500 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0006353; P:DNA-dependent transcription, termination; IEA:UniProtKB-KW.
 GO:0031564; P:transcription antitermination; IEA:UniProtKB-KW. 
Interpro
 IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
 IPR004087; KH_dom.
 IPR015946; KH_dom-like_a/b.
 IPR025249; KH_dom_NusA-like.
 IPR004088; KH_dom_type_1.
 IPR009019; KH_prok-type.
 IPR012340; NA-bd_OB-fold.
 IPR003029; Rbsml_prot_S1_RNA-bd_dom.
 IPR022967; RNA-binding_domain_S1.
 IPR013735; TF_NusA_N.
 IPR010214; Tscrpt_termin_fac_NusA_C_rpt.
 IPR010213; Tscrpt_termination_fac_NusA. 
Pfam
 PF13184; KH_5
 PF08529; NusA_N
 PF00575; S1 
SMART
 SM00322; KH
 SM00316; S1 
PROSITE
 PS50084; KH_TYPE_1
 PS50126; S1 
PRINTS