UniProt Accession

 BIN1_HUMAN; O00499; O00297; O00545; O43867; O60552; O60553; O60554; O60555; O75514; O75515; O75516; O75517; O75518; Q659B7; Q92944; Q99688 

Genbank Protein ID

 AF004015; AF070576; AF001383; U68485; AF043898; AF043899; AF043900; AF043901; U87558; AF068914; AF068915; AF068916; AF068917; AF068918; U84004; U83999; U84001; U84002; U84003; U84004; U83999; U84001; U84002; U84003; AL713697; AC012508; CH471103 

Genbank Nucleotide ID

 AAC51345.1; AAC28646.1; AAB61363.1; AAC17461.1; AAC39710.1; AAC39711.1; AAC39712.1; AAC39713.1; AAB63263.1; AAC24126.1; AAC24127.1; AAC24128.1; AAC23750.1; AAC23751.1; AAC23440.1; AAC23440.1; AAC23440.1; AAC23440.1; AAC23440.1; AAC23441.1; AAC23441.1; AAC23441.1; AAC23441.1; AAC23441.1; CAD28496.1; AAY24328.1; EAW95302.1 

Protein Name

 Myc box-dependent-interacting protein 1 

Protein Synonyms/Alias

 Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1 

Gene Name

 BIN1 

Gene Synonyms/Alias

 AMPHL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
173	KDEAKIAKAEEELIK	acetylation	[1]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 

Functional Description

 May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation. 

Sequence Annotation

 DOMAIN 29 276 BAR.
 DOMAIN 520 592 SH3.
 REGION 1 122 Interaction with BIN2.
 REGION 378 421 Clathrin-binding.
 MOD_RES 296 296 Phosphoserine.
 MOD_RES 298 298 Phosphoserine.
 MOD_RES 303 303 Phosphoserine.
 MOD_RES 307 307 Phosphothreonine.
 MOD_RES 323 323 Phosphothreonine.
 MOD_RES 331 331 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Disease mutation; Endocytosis; Host-virus interaction; Nucleus; Phosphoprotein; Reference proteome; SH3 domain; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 593 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
 GO:0043679; C:axon terminus; IEA:Compara.
 GO:0044300; C:cerebellar mossy fiber; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:LIFEdb.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0043196; C:varicosity; IEA:Compara.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0042692; P:muscle cell differentiation; IEA:Compara.
 GO:0045807; P:positive regulation of endocytosis; IEA:Compara.
 GO:0043547; P:positive regulation of GTPase activity; IEA:Compara.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR027267; AH/BAR-dom.
 IPR003005; Amphiphysin.
 IPR003023; Amphiphysin_2.
 IPR004148; BAR_dom.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 

Pfam

 PF03114; BAR
 PF07653; SH3_2 

SMART

 SM00721; BAR
 SM00326; SH3 

PROSITE

 PS51021; BAR
 PS50002; SH3 

PRINTS

 PR01251; AMPHIPHYSIN.
 PR01253; AMPHIPHYSIN2.
 PR00452; SH3DOMAIN.