UniProt Accession

 UBCD1_DROME; P25867; Q9VFG6 

Genbank Protein ID

 X62575; AE014297; AY060304; U68298 

Genbank Nucleotide ID

 CAA44453.1; AAF55093.1; AAL25343.1; AAB39622.1 

Protein Name

 Ubiquitin-conjugating enzyme E2-17 kDa 

Protein Synonyms/Alias

 Protein effete; Ubiquitin carrier protein; Ubiquitin-protein ligase 

Gene Name

 eff 

Gene Synonyms/Alias

 UbcD1; CG7425 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
8	MALKRINKELQDLGR	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Required for proper telomere behavior during cell divisions and possibly for ubiquitination of proteins involved in postmeiotic stages of spermatogenesis. Deletion mutations are lethal in homozygotes. 

Sequence Annotation

 ACT_SITE 85 85 Glycyl thioester intermediate (By  

Keyword

 ATP-binding; Cell cycle; Cell division; Complete proteome; Ligase; Meiosis; Nucleotide-binding; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004842; F:ubiquitin-protein ligase activity; IGI:FlyBase.
 GO:0051276; P:chromosome organization; IMP:FlyBase.
 GO:0001751; P:compound eye photoreceptor cell differentiation; IMP:FlyBase.
 GO:0008054; P:cyclin catabolic process; IMP:FlyBase.
 GO:0048132; P:female germ-line stem cell division; IMP:FlyBase.
 GO:0030718; P:germ-line stem cell maintenance; IMP:FlyBase.
 GO:0007140; P:male meiosis; IMP:FlyBase.
 GO:0007067; P:mitosis; IMP:FlyBase.
 GO:0016322; P:neuron remodeling; IDA:FlyBase.
 GO:0031647; P:regulation of protein stability; IMP:FlyBase.
 GO:0045676; P:regulation of R7 cell differentiation; IGI:FlyBase.
 GO:0007286; P:spermatid development; IMP:FlyBase. 

Interpro

 IPR000608; UBQ-conjugat_E2.
 IPR023313; UBQ-conjugating_AS.
 IPR016135; UBQ-conjugating_enzyme/RWD. 

Pfam

 PF00179; UQ_con 

SMART

  

PROSITE

 PS00183; UBIQUITIN_CONJUGAT_1
 PS50127; UBIQUITIN_CONJUGAT_2 

PRINTS