CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010768
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Interleukin-6 receptor subunit beta 
Protein Synonyms/Alias
 IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD130 
Gene Name
 Il6st 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
647NKRDLIKKHIWPNVPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development. 
Sequence Annotation
 DOMAIN 26 120 Ig-like C2-type.
 DOMAIN 125 214 Fibronectin type-III 1.
 DOMAIN 220 319 Fibronectin type-III 2.
 DOMAIN 324 416 Fibronectin type-III 3.
 DOMAIN 421 512 Fibronectin type-III 4.
 DOMAIN 514 608 Fibronectin type-III 5.
 MOTIF 308 312 WSXWS motif.
 MOTIF 649 657 Box 1 motif.
 MOD_RES 665 665 Phosphoserine (By similarity).
 MOD_RES 780 780 Phosphoserine (By similarity).
 MOD_RES 827 827 Phosphoserine (By similarity).
 CARBOHYD 43 43 N-linked (GlcNAc...) (Potential).
 CARBOHYD 61 61 N-linked (GlcNAc...) (Potential).
 CARBOHYD 83 83 N-linked (GlcNAc...) (Potential).
 CARBOHYD 131 131 N-linked (GlcNAc...) (Potential).
 CARBOHYD 157 157 N-linked (GlcNAc...) (Potential).
 CARBOHYD 225 225 N-linked (GlcNAc...).
 CARBOHYD 388 388 N-linked (GlcNAc...) (Potential).
 CARBOHYD 476 476 N-linked (GlcNAc...) (Potential).
 CARBOHYD 551 551 N-linked (GlcNAc...) (Potential).
 DISULFID 28 54 By similarity.
 DISULFID 48 103 By similarity.
 DISULFID 134 144 By similarity.
 DISULFID 172 180 By similarity.
 DISULFID 456 464 By similarity.  
Keyword
 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 917 AA 
Protein Sequence
MSAPRIWLAQ ALLFFLTTES IGQLLEPCGY IYPEFPVVQR GSNFTAICVL KEACLQHYYV 60
NASYIVWKTN HAAVPREQVT VINRTTSSVT FTDVVLPSVQ LTCNILSFGQ IEQNVYGVTM 120
LSGFPPDKPT NLTCIVNEGK NMLCQWDPGR ETYLETNYTL KSEWATEKFP DCQSKHGTSC 180
MVSYMPTYYV NIEVWVEAEN ALGKVSSESI NFDPVDKVKP TPPYNLSVTN SEELSSILKL 240
SWVSSGLGGL LDLKSDIQYR TKDASTWIQV PLEDTMSPRT SFTVQDLKPF TEYVFRIRSI 300
KDSGKGYWSD WSEEASGTTY EDRPSRPPSF WYKTNPSHGQ EYRSVRLIWK ALPLSEANGK 360
ILDYEVILTQ SKSVSQTYTV TGTELTVNLT NDRYVASLAA RNKVGKSAAA VLTIPSPHVT 420
AAYSVVNLKA FPKDNLLWVE WTPPPKPVSK YILEWCVLSE NAPCVEDWQQ EDATVNRTHL 480
RGRLLESKCY QITVTPVFAT GPGGSESLKA YLKQAAPARG PTVRTKKVGK NEAVLAWDQI 540
PVDDQNGFIR NYSISYRTSV GKEMVVHVDS SHTEYTLSSL SSDTLYMVRM AAYTDEGGKD 600
GPEFTFTTPK FAQGEIEAIV VPVCLAFLLT TLLGVLFCFN KRDLIKKHIW PNVPDPSKSH 660
IAQWSPHTPP RHNFNSKDQM YSDGNFTDVS VVEIEANNKK PCPDDLKSVD LFKKEKVSTE 720
GHSSGIGGSS CMSSSRPSIS SNEENESAQS TASTVQYSTV VHSGYRHQVP SVQVFSRSES 780
TQPLLDSEER PEDLQLVDSV DGGDEILPRQ PYFKQNCSQP EACPEISHFE RSNQVLSGNE 840
EDFVRLKQQQ VSDHISQPYG SEQRRLFQEG STADALGTGA DGQMERFESV GMETTIDEEI 900
PKSYLPQTVR QGGYMPQ 917 
Gene Ontology
 GO:0070110; C:ciliary neurotrophic factor receptor complex; IEA:Compara.
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005896; C:interleukin-6 receptor complex; IEA:Compara.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0005900; C:oncostatin-M receptor complex; IEA:Compara.
 GO:0004915; F:interleukin-6 receptor activity; IEA:Compara.
 GO:0004923; F:leukemia inhibitory factor receptor activity; IEA:Compara.
 GO:0004924; F:oncostatin-M receptor activity; IEA:Compara.
 GO:0005977; P:glycogen metabolic process; IMP:MGI.
 GO:0038154; P:interleukin-11-mediated signaling pathway; IDA:GOC.
 GO:0070106; P:interleukin-27-mediated signaling pathway; IEA:Compara.
 GO:0070104; P:negative regulation of interleukin-6-mediated signaling pathway; IEA:Compara.
 GO:0048711; P:positive regulation of astrocyte differentiation; IMP:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IGI:MGI.
 GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Compara.
 GO:0042102; P:positive regulation of T cell proliferation; IEA:Compara.
 GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein; IEA:Compara.
 GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Compara.
 GO:0008593; P:regulation of Notch signaling pathway; IDA:MGI. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR003529; Hematopoietin_rcpt_Gp130_CS.
 IPR013783; Ig-like_fold.
 IPR010457; IgC2-like_lig-bd.
 IPR015321; IL6_recept-bd. 
Pfam
 PF00041; fn3
 PF09240; IL6Ra-bind
 PF06328; Lep_receptor_Ig 
SMART
 SM00060; FN3 
PROSITE
 PS50853; FN3
 PS01353; HEMATOPO_REC_L_F2 
PRINTS