UniProt Accession

 NDUV3_HUMAN; P56181; A8K0M1; J3KNX7; Q6FGD3; Q8WU60; Q9HCR5 

Genbank Protein ID

 X99726; X99727; X99728; AB038163; CR542174; CR542190; AK289586; AP001629; CH471079; CH471079; BC021217; BC033766; BC054016 

Genbank Nucleotide ID

 CAB56704.1; CAB56704.1; CAB56704.1; BAB13732.1; CAG46971.1; CAG46987.1; BAF82275.1; EAX09524.1; EAX09526.1; AAH21217.2; AAH33766.1; AAH54016.1 

Protein Name

 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 

Protein Synonyms/Alias

 Complex I-9kD; CI-9kD; NADH-ubiquinone oxidoreductase 9 kDa subunit; Renal carcinoma antigen NY-REN-4 

Gene Name

 NDUFV3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
127	TLVEFPQKVLSPFRK	ubiquitination	[1]
223	VDITDPEKPHQPKKK	acetylation	[2]
336	AAEGHLEKPVPEPQR	acetylation	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Respiratory chain; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 108 AA 

Protein Sequence

Gene Ontology

 GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
 GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR026193; NDUFV3. 

Pfam

  

SMART

  

PROSITE

  

PRINTS