UniProt Accession

 XRCC2_HUMAN; O43543; B2R925 

Genbank Protein ID

 AF035587; AC003109; Y08837; Y17033; AF520762; AK313607; CH471173; BC042137 

Genbank Nucleotide ID

 AAC05369.1; AAC05802.1; CAA70065.1; CAA76597.1; AAM55241.1; BAG36372.1; EAW53968.1; AAH42137.1 

Protein Name

 DNA repair protein XRCC2 

Protein Synonyms/Alias

 X-ray repair cross-complementing protein 2 

Gene Name

 XRCC2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
243	KHRMFFSKQDDSQSS	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. 

Sequence Annotation

  

Keyword

 Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleus; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 280 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008094; F:DNA-dependent ATPase activity; IEA:InterPro.
 GO:0006281; P:DNA repair; IGI:BHF-UCL.
 GO:0000724; P:double-strand break repair via homologous recombination; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0007126; P:meiosis; TAS:ProtInc.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0050769; P:positive regulation of neurogenesis; IEA:Compara.
 GO:0010332; P:response to gamma radiation; IEA:Compara.
 GO:0010165; P:response to X-ray; IEA:Compara. 

Interpro

 IPR013632; DNA_recomb/repair_Rad51_C.
 IPR020588; DNA_recomb_RecA/RadB_ATP-bd.
 IPR027417; P-loop_NTPase. 

Pfam

 PF08423; Rad51 

SMART

  

PROSITE

 PS50162; RECA_2 

PRINTS