UniProt Accession

 H0Y8I7_HUMAN; H0Y8I7 

Genbank Protein ID

 AC016255; AC083905 

Genbank Nucleotide ID

  

Protein Name

 DNA topoisomerase 2-binding protein 1 

Protein Synonyms/Alias

  

Gene Name

 TOPBP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
23	WIKTLWEKSQEKKIT	ubiquitination	[1]
69	EVQQLTVKHGGQYMG	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 206 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR001357; BRCT_dom.
 IPR026993; Topbp1. 

Pfam

 PF12738; PTCB-BRCT 

SMART

 SM00292; BRCT 

PROSITE

 PS50172; BRCT 

PRINTS