UniProt Accession

 ATS12_HUMAN; P58397; A2RRN9; A5D6V6; Q6UWL3 

Genbank Protein ID

 AJ250725; AY358745; AC008880; AC034232; AC109491; AC139777; BC058841; BC131733; BC139900 

Genbank Nucleotide ID

 CAC20419.1; AAQ89105.1; AAH58841.1; AAI31734.1; AAI39901.1 

Protein Name

 A disintegrin and metalloproteinase with thrombospondin motifs 12 

Protein Synonyms/Alias

 ADAM-TS 12; ADAM-TS12; ADAMTS-12 

Gene Name

 ADAMTS12 

Gene Synonyms/Alias

 UNQ1918/PRO4389 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
536	GKCITVGKKPESIPG	methylation	[1]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

 Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. 

Sequence Annotation

 DOMAIN 246 456 Peptidase M12B.
 DOMAIN 465 544 Disintegrin.
 DOMAIN 542 597 TSP type-1 1.
 DOMAIN 823 883 TSP type-1 2.
 DOMAIN 887 943 TSP type-1 3.
 DOMAIN 944 997 TSP type-1 4.
 DOMAIN 1313 1366 TSP type-1 5.
 DOMAIN 1368 1422 TSP type-1 6.
 DOMAIN 1423 1471 TSP type-1 7.
 DOMAIN 1472 1532 TSP type-1 8.
 DOMAIN 1535 1575 PLAC.
 REGION 701 827 Spacer 1.
 REGION 997 1316 Spacer 2.
 MOTIF 208 213 Cysteine switch (By similarity).
 ACT_SITE 393 393 By similarity.
 METAL 208 208 Zinc; in inhibited form (By similarity).
 METAL 392 392 Zinc; catalytic (By similarity).
 METAL 396 396 Zinc; catalytic (By similarity).
 METAL 402 402 Zinc; catalytic (By similarity).
 MOD_RES 982 982 Phosphothreonine (By similarity).
 CARBOHYD 105 105 N-linked (GlcNAc...) (Potential).
 CARBOHYD 125 125 N-linked (GlcNAc...) (Potential).
 CARBOHYD 215 215 N-linked (GlcNAc...) (Potential).
 CARBOHYD 485 485 N-linked (GlcNAc...) (Potential).
 CARBOHYD 685 685 N-linked (GlcNAc...) (Potential).
 CARBOHYD 790 790 N-linked (GlcNAc...) (Potential).
 CARBOHYD 952 952 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1105 1105 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1276 1276 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1301 1301 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1321 1321 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1372 1372 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1379 1379 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1504 1504 N-linked (GlcNAc...) (Potential).
 DISULFID 370 451 By similarity.
 DISULFID 409 435 By similarity.
 DISULFID 554 591 By similarity.
 DISULFID 558 596 By similarity.
 DISULFID 569 581 By similarity.  

Keyword

 Alternative splicing; Cleavage on pair of basic residues; Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein; Hydrolase; Metal-binding; Metalloprotease; Phosphoprotein; Polymorphism; Protease; Reference proteome; Repeat; Secreted; Signal; Zinc; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1594 AA 

Protein Sequence

Gene Ontology

 GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR010294; ADAM_spacer1.
 IPR024079; MetalloPept_cat_dom.
 IPR001590; Peptidase_M12B.
 IPR013273; Peptidase_M12B_ADAM-TS.
 IPR002870; Peptidase_M12B_N.
 IPR010909; PLAC.
 IPR000884; Thrombospondin_1_rpt. 

Pfam

 PF05986; ADAM_spacer1
 PF01562; Pep_M12B_propep
 PF01421; Reprolysin
 PF00090; TSP_1 

SMART

 SM00209; TSP1 

PROSITE

 PS50215; ADAM_MEPRO
 PS00546; CYSTEINE_SWITCH
 PS00427; DISINTEGRIN_1
 PS50214; DISINTEGRIN_2
 PS50900; PLAC
 PS50092; TSP1
 PS00142; ZINC_PROTEASE 

PRINTS

 PR01857; ADAMTSFAMILY.