CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040110
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Prohibitin-2 
Protein Synonyms/Alias
  
Gene Name
 Phb2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
74RAQFLVEKAKQEQRQacetylation[1, 2]
82AKQEQRQKIVQAEGEubiquitination[3]
94EGEAEAAKMLGEALSacetylation[1, 2, 4]
102MLGEALSKNPGYIKLacetylation[2]
108SKNPGYIKLRKIRAAacetylation[5]
108SKNPGYIKLRKIRAAsuccinylation[5]
120RAAQNISKTIATSQNacetylation[1]
120RAAQNISKTIATSQNubiquitination[3]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 157 AA 
Protein Sequence
XSPTGSKDLQ MVNISLRVLS RPNAQELPSM YQRLGLDYEE RVLPSIVNEV LKSVVAKFNA 60
SQLITQRAQF LVEKAKQEQR QKIVQAEGEA EAAKMLGEAL SKNPGYIKLR KIRAAQNISK 120
TIATSQNRIY LTADNLVLNL QDESFTRGSD SLIKGKK 157 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0060749; P:mammary gland alveolus development; IMP:MGI.
 GO:0060744; P:mammary gland branching involved in thelarche; IMP:MGI.
 GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; IMP:MGI.
 GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IMP:MGI.
 GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IMP:MGI. 
Interpro
 IPR000163; Prohibitin. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR00679; PROHIBITIN.