CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002210
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Secretogranin-1 
Protein Synonyms/Alias
 Chromogranin-B; CgB; Secretogranin I; SgI; GAWK peptide; CCB peptide 
Gene Name
 CHGB 
Gene Synonyms/Alias
 SCG1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
482GEEGAPGKWQQQGDLubiquitination[1]
586DVNWGYEKRNLARVPubiquitination[1]
598RVPKLDLKRQYDRVAacetylation[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. 
Sequence Annotation
 REGION 116 120 O-glycosylated at one site.
 MOD_RES 79 79 Phosphothreonine (Probable).
 MOD_RES 99 99 Phosphoserine (Potential).
 MOD_RES 100 100 Phosphoserine (Potential).
 MOD_RES 149 149 Phosphoserine.
 MOD_RES 153 153 N6-acetyllysine (By similarity).
 MOD_RES 183 183 Phosphoserine (By similarity).
 MOD_RES 259 259 Phosphoserine.
 MOD_RES 263 263 Phosphoserine.
 MOD_RES 293 293 Phosphoserine (Potential).
 MOD_RES 294 294 Phosphoserine (Potential).
 MOD_RES 311 311 Phosphoserine.
 MOD_RES 335 335 Phosphoserine.
 MOD_RES 341 341 Sulfotyrosine (By similarity).
 MOD_RES 377 377 Phosphoserine (By similarity).
 MOD_RES 380 380 Phosphoserine.
 MOD_RES 405 405 Phosphoserine.
 MOD_RES 471 471 Sulfotyrosine (Potential).
 MOD_RES 474 474 Sulfotyrosine (Probable).
 MOD_RES 533 533 Phosphoserine (Potential).
 MOD_RES 534 534 Phosphoserine (Potential).
 MOD_RES 566 566 Sulfotyrosine (Probable).
 MOD_RES 568 568 Sulfotyrosine (Potential).
 MOD_RES 617 617 Phosphoserine.
 MOD_RES 624 624 Sulfotyrosine (By similarity).
 MOD_RES 626 626 Phosphoserine (By similarity).
 MOD_RES 631 631 Phosphoserine (By similarity).
 DISULFID 36 57  
Keyword
 Acetylation; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal; Sulfation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 677 AA 
Protein Sequence
MQPTLLLSLL GAVGLAAVNS MPVDNRNHNE GMVTRCIIEV LSNALSKSSA PPITPECRQV 60
LKTSRKDVKD KETTENENTK FEVRLLRDPA DASEAHESSS RGEAGAPGEE DIQGPTKADT 120
EKWAEGGGHS RERADEPQWS LYPSDSQVSE EVKTRHSEKS QREDEEEEEG ENYQKGERGE 180
DSSEEKHLEE PGETQNAFLN ERKQASAIKK EELVARSETH AAGHSQEKTH SREKSSQESG 240
EETGSQENHP QESKGQPRSQ EESEEGEEDA TSEVDKRRTR PRHHHGRSRP DRSSQGGSLP 300
SEEKGHPQEE SEESNVSMAS LGEKRDHHST HYRASEEEPE YGEEIKGYPG VQAPEDLEWE 360
RYRGRGSEEY RAPRPQSEES WDEEDKRNYP SLELDKMAHG YGEESEEERG LEPGKGRHHR 420
GRGGEPRAYF MSDTREEKRF LGEGHHRVQE NQMDKARRHP QGAWKELDRN YLNYGEEGAP 480
GKWQQQGDLQ DTKENREEAR FQDKQYSSHH TAEKRKRLGE LFNPYYDPLQ WKSSHFERRD 540
NMNDNFLEGE EENELTLNEK NFFPEYNYDW WEKKPFSEDV NWGYEKRNLA RVPKLDLKRQ 600
YDRVAQLDQL LHYRKKSAEF PDFYDSEEPV STHQEAENEK DRADQTVLTE DEKKELENLA 660
AMDLELQKIA EKFSQRG 677 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0030141; C:secretory granule; IEA:Compara.
 GO:0005179; F:hormone activity; TAS:ProtInc. 
Interpro
 IPR001819; Chromogranin_AB.
 IPR018054; Chromogranin_CS.
 IPR001990; Granin. 
Pfam
 PF01271; Granin 
SMART
  
PROSITE
 PS00422; GRANINS_1
 PS00423; GRANINS_2 
PRINTS
 PR00659; CHROMOGRANIN.