CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013434
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 4-hydroxybenzoate--CoA/benzoate--CoA ligase 
Protein Synonyms/Alias
 4-hydroxybenzoyl-CoA synthetase 
Gene Name
 hbaA 
Gene Synonyms/Alias
 RPA0669 
Created Date
 July 27, 2013 
Organism
 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 
NCBI Taxa ID
 258594 
Lysine Modification
Position
Peptide
Type
References
503LPKTSSGKLQRYLLRacetylation[1, 2]
Reference
 [1] Reversible N epsilon-lysine acetylation regulates the activity of acyl-CoA synthetases involved in anaerobic benzoate catabolism in Rhodopseudomonas palustris.
 Crosby HA, Heiniger EK, Harwood CS, Escalante-Semerena JC.
 Mol Microbiol. 2010 May;76(4):874-88. [PMID: 20345662]
 [2] System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.
 Crosby HA, Pelletier DA, Hurst GB, Escalante-Semerena JC.
 J Biol Chem. 2012 May 4;287(19):15590-601. [PMID: 22416131] 
Functional Description
 Catalyzes the ligation of 4-hydroxybenzoate, benzoate or cyclohex-1,4-dienecarboxylate and CoA at the expense of ATP. The enzyme shows low activity towards cyclo-2,5-dienecarboxylate, 4- fluorobenzoate, 4-chlorobenzoate and 2-methoxybenzoate. 
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Ligase; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 539 AA 
Protein Sequence
MPLRDYNAAV DFVDRNVAEG RGGKIAFIDP QRSLSYGELR DAVARVGPML ARLGVEQENR 60
IALVLKDTVD FPILFWGAIR AGIVPVLLNT RLTADQYRYL LEDSRSRVVF ASSEFLPVIE 120
EAAADLPHLR TIIAVGDAPA PTLQLANLLA TEQEGGAPAA TCADDIAYWQ YSSGTTGMPK 180
GVMHVHSSPR VMAENAGRRI GYREDDVVFS AAKLFFAYGL GNAMFCPMGI GATSVLYPER 240
PTADSVFDTL RLHQPTLLFA VPTLYAAMLA DPRSRTETLP DRLRLCVSAG EPLPAQVGLN 300
WRNRFGHDIV NGVGSTEMGH LFLTNLPHAV EYGTSGVPVD GYRLRLVGDR GQDVADDEIG 360
ELLVSGGSSA AGYWNQRDKT RTTFVGEWTR TGDKYHRRAD GVYTYCGRTD DIFKVSGIWV 420
SPFEIEQALM SHAKVLEAAV IPAEDTDGLI KPKAFIVLAS RGDIDPGALF DELKEHVKSA 480
IGPWKYPRWI QIMDDLPKTS SGKLQRYLLR EMTLGGIEAT ESAPSEPALY GRVVAGNGR 539 
Gene Ontology
 GO:0018859; F:4-hydroxybenzoate-CoA ligase activity; IEA:EC.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0018858; F:benzoate-CoA ligase activity; IEA:EC. 
Interpro
 IPR000873; AMP-dep_Synth/Lig.
 IPR011957; Benz_CoA_lig.
 IPR025110; DUF4009. 
Pfam
 PF00501; AMP-binding
 PF13193; DUF4009 
SMART
  
PROSITE
  
PRINTS