| Tag | Content |
|---|
| CPLM ID | CPLM-015131 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform |
Protein Synonyms/Alias | PP2A subunit B isoform B55-alpha; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform alpha |
Gene Name | Ppp2r2a |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 62 | FQQEQENKIQSHSRG | ubiquitination | [1] | | 105 | KIRWLPQKNAAQFLL | ubiquitination | [1] | | 129 | WKISERDKRPEGYNL | ubiquitination | [1] | | 267 | ALCDRHSKLFEEPED | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). |
Sequence Annotation | REPEAT 26 65 WD 1.
REPEAT 91 132 WD 2.
REPEAT 175 213 WD 3.
REPEAT 224 264 WD 4.
REPEAT 283 321 WD 5.
REPEAT 338 379 WD 6.
REPEAT 414 446 WD 7.
MOD_RES 2 2 N-acetylalanine (By similarity). |
Keyword | Acetylation; Complete proteome; Direct protein sequencing; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 447 AA |
Protein Sequence | MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG RVVIFQQEQE 60
NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQKNAAQF LLSTNDKTIK 120
LWKISERDKR PEGYNLKEED GRYRDPTTVT TLRVPVFRPM DLMVEASPRR IFANAHTYHI 180
NSISINSDYE TYLSADDLRI NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN 240
TFVYSSSKGT IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM 300
MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW NGSDSVVMTG 360
SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS GKRKKDEISV DSLDFNKKIL 420
HTAWHPKENI IAVATTNNLY IFQDKVN 447 |
Gene Ontology | GO:0000159; C:protein phosphatase type 2A complex; IEA:InterPro. GO:0008601; F:protein phosphatase type 2A regulator activity; IEA:InterPro. GO:0004722; F:protein serine/threonine phosphatase activity; IEA:Compara. GO:0006470; P:protein dephosphorylation; IEA:Compara. GO:0043278; P:response to morphine; IMP:MGI. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |