CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000542
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neurochondrin 
Protein Synonyms/Alias
 Neurite outgrowth-related protein from the rat brain; Norbin 
Gene Name
 Ncdn 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
71KAGDIDAKTRRRIFDubiquitination[1]
272LARILGSKLSSWQRNacetylation[2]
283WQRNPALKLAARLAHubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)- calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. 
Sequence Annotation
 MOD_RES 2 2 N-acetylserine (By similarity).  
Keyword
 Acetylation; Cell projection; Complete proteome; Cytoplasm; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 729 AA 
Protein Sequence
MSCCDLAAAG QLGKAGIMAS DCEPALNQAE SRNPTLERYL GALREAKNDS EQFAALLLVT 60
KAVKAGDIDA KTRRRIFDAV GFTFPNRLLT TKEAPDGCPD HVLRALGVAL LACFCSDPEL 120
ASHPQVLNKI PILCTFLTAR GDPDDAARRS MIDDTYQCLT AVAGTPRGPR HLIAGGTVSA 180
LCQAYLGHGY GFDQALALLV GLLAAAETQC WKEAEPDLLA VLRGLSEDFQ RAEDASKFEL 240
CQLLPLFLPP TTVPPECHRD LQAGLARILG SKLSSWQRNP ALKLAARLAH ACGSDWIPVG 300
SSGSKFLALL VNLACVEVRL ALEETGTEVK EDVVTACYAL MELGIQECTR CEQSLLKEPQ 360
KVQLVSIMKE AIGAVIHYLL RVGPEKQKEP FVFASVRILG AWLAEETSSL RKEVCQLLPF 420
LVRYAKTLYE EAEEASDISQ QVANLAISPT TPGPAWPGDA LRLLLPGWCH LTVEDGPREI 480
LIKEGAPSLL CKYFLQQWEL TSPGHDTSVL PDSVEIGLQT CCHIFLNLVV TAPGLIKRDA 540
CFTSLMNTLM TSLPSLVQQQ GRLLLAANVA TLGLLMARLL STSPALQGTP ASRGFFAAAI 600
LFLSQSHVAR ATPGSDQAVL ALSPDYEGIW ADLQELWFLG MQAFTGCVPL LPWLAPAALR 660
SRWPQELLQL LGSVSPNSVK PEMVAAYQGV LVELARANRL CREAMRLQAG EETASHYRMA 720
ALEQCLSEP 729 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0030425; C:dendrite; IDA:UniProtKB.
 GO:0043025; C:neuronal cell body; IDA:UniProtKB.
 GO:0045453; P:bone resorption; IEA:Compara.
 GO:0031175; P:neuron projection development; IEP:UniProtKB.
 GO:0048168; P:regulation of neuronal synaptic plasticity; IDA:RGD. 
Interpro
 IPR008709; Neurochondrin. 
Pfam
  
SMART
  
PROSITE
  
PRINTS