CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034223
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transcription factor A, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Tfam 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
22FSTEQLPKFKAKHPDacetylation[1, 2]
22FSTEQLPKFKAKHPDsuccinylation[2]
26QLPKFKAKHPDAKLSacetylation[3]
38KLSELVRKIAALWREacetylation[4]
63ADFKAEWKAYKEAVSacetylation[1]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 143 AA 
Protein Sequence
MGSYPKKPMS SYLRFSTEQL PKFKAKHPDA KLSELVRKIA ALWRELPEAE KKVYEADFKA 60
EWKAYKEAVS KYKEQLTPSQ LMGMEKEARQ RRLKKKALVK RRELILLGKP KRPRSAYNIY 120
VSESFQEAKD DSAQGKLKLV NEA 143 
Gene Ontology
 GO:0042645; C:mitochondrial nucleoid; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005667; C:transcription factor complex; TAS:MGI.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0008301; F:DNA binding, bending; IEA:Compara.
 GO:0070363; F:mitochondrial light strand promoter sense binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:MGI.
 GO:0033108; P:mitochondrial respiratory chain complex assembly; IMP:MGI.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0006391; P:transcription initiation from mitochondrial promoter; IEA:Compara. 
Interpro
 IPR009071; HMG_box_dom. 
Pfam
 PF00505; HMG_box 
SMART
 SM00398; HMG 
PROSITE
 PS50118; HMG_BOX_2 
PRINTS