Tag | Content |
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CPLM ID | CPLM-008264 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sulfotransferase 1A3/1A4 |
Protein Synonyms/Alias | ST1A3/ST1A4; Aryl sulfotransferase 1A3/1A4; Catecholamine-sulfating phenol sulfotransferase; HAST3; M-PST; Monoamine-sulfating phenol sulfotransferase; Placental estrogen sulfotransferase; Sulfotransferase, monoamine-preferring; Thermolabile phenol sulfotransferase; TL-PST |
Gene Name | SULT1A3; SULT1A4 |
Gene Synonyms/Alias | STM |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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97 | PSGLETLKDTPPPRL | ubiquitination | [1] |
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Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs. |
Sequence Annotation | NP_BIND 48 53 PAPS. NP_BIND 227 232 PAPS. NP_BIND 257 259 PAPS. REGION 106 108 Substrate binding. ACT_SITE 108 108 Proton acceptor (By similarity). BINDING 86 86 Substrate. BINDING 130 130 PAPS. BINDING 138 138 PAPS. BINDING 146 146 Substrate. BINDING 193 193 PAPS. |
Keyword | 3D-structure; Alternative splicing; Catecholamine metabolism; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid metabolism; Reference proteome; Steroid metabolism; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 295 AA |
Protein Sequence | MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLINTYPKSG TTWVSQILDM 60 IYQGGDLEKC NRAPIYVRVP FLEVNDPGEP SGLETLKDTP PPRLIKSHLP LALLPQTLLD 120 QKVKVVYVAR NPKDVAVSYY HFHRMEKAHP EPGTWDSFLE KFMAGEVSYG SWYQHVQEWW 180 ELSRTHPVLY LFYEDMKENP KREIQKILEF VGRSLPEETM DFMVQHTSFK EMKKNPMTNY 240 TTVPQELMDH SISPFMRKGM AGDWKTTFTV AQNERFDADY AEKMAGCSLS FRSEL 295 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0004062; F:aryl sulfotransferase activity; TAS:Reactome. GO:0050427; P:3'-phosphoadenosine 5'-phosphosulfate metabolic process; TAS:Reactome. GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome. GO:0006584; P:catecholamine metabolic process; IEA:UniProtKB-KW. GO:0044267; P:cellular protein metabolic process; TAS:Reactome. GO:0009812; P:flavonoid metabolic process; IDA:BHF-UCL. GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW. GO:0051923; P:sulfation; IDA:BHF-UCL. GO:0006805; P:xenobiotic metabolic process; IDA:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |