Tag | Content |
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CPLM ID | CPLM-024672 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vacuolar protein sorting-associated protein 29 |
Protein Synonyms/Alias | Vesicle protein sorting 29 |
Gene Name | Vps29 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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50 | KESYDYLKTLAGDVH | acetylation | [1] | 73 | SLNYPEQKVVTVGQF | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). |
Sequence Annotation | METAL 8 8 Zinc 1 (By similarity). METAL 10 10 Zinc 1 (By similarity). METAL 39 39 Zinc 1 (By similarity). METAL 39 39 Zinc 2 (By similarity). METAL 62 62 Zinc 2 (By similarity). METAL 86 86 Zinc 2 (By similarity). METAL 115 115 Zinc 2 (By similarity). METAL 117 117 Zinc 1 (By similarity). MOD_RES 50 50 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Endosome; Hydrolase; Membrane; Metal-binding; Protein transport; Reference proteome; Transport; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 182 AA |
Protein Sequence | MLVLVLGDLH IPHRCNSLPA KFKKLLVPGK IQHILCTGNL CTKESYDYLK TLAGDVHIVR 60 GDFDESLNYP EQKVVTVGQF KIGLIHGHQV IPWGDMASLA LLQRQFDVDI LISGHTHKFE 120 AFEHENKFYI NPGSATGAYN ALETNIIPSF VLMDIQASTV VTYVYQLIGD DVKVERIEYK 180 KS 182 |
Gene Ontology | GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004647; F:phosphoserine phosphatase activity; IEA:EC. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
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