CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020435
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transport and Golgi organization protein 6 homolog 
Protein Synonyms/Alias
 Transmembrane and coiled-coil domain-containing protein 7 
Gene Name
 TANGO6 
Gene Synonyms/Alias
 KIAA1746; TMCO7 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
63ALEDKFLKDPQWKNLmethylation[1]
238GFCPTKRKLLTPAEEubiquitination[2]
290PQSCTDVKTQMRCRAubiquitination[2, 3]
348EVTAADWKKCDLIAKubiquitination[4, 5]
349VTAADWKKCDLIAKIubiquitination[2]
567EDEALYQKVSSEQGRubiquitination[4]
719SSDFAVLKQLLPLLEubiquitination[2]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
  
Sequence Annotation
 REPEAT 873 909 HEAT 1.
 REPEAT 952 988 HEAT 2.  
Keyword
 Complete proteome; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1094 AA 
Protein Sequence
MAARQAVGSG AQETCGLDRI LEALKLLLSP GGSGSSSLQV TKHDVLLATL KSNLSALEDK 60
FLKDPQWKNL KLLRDEIADK AEWPQNSVDV TWSFTSQTLL LLLCLKETMI RLAANFNPGK 120
PNPRTPEVAP ALSPDALSIS QQKTVQFVLQ FVVTLGICPY LMPGVGVPLR YRTEFGAVVQ 180
DVVCFDAAPD ATRRLYTSCK ALLNVAQHTS LGSLIFCHHF GDIAAGLCQL GFCPTKRKLL 240
TPAEEVLTEE ERTLSRGALR DMLDQVYQPL AVRELLILQG GPPQSCTDVK TQMRCRAPAW 300
LRRLCGQLLS ERLMRPNGVQ AVVRGILEGA GAGAAGGSDA EVTAADWKKC DLIAKILASC 360
PQQSLSPENY YRDICPQVLD LFHFQDKLTA RQFQRVATTT FITLSRERPH LAAKYLLQPV 420
LAPLHRCLNT AELSESDMVP GTILVTEEEL SRCIEDVFKV YVVGNEPLTV LMDSLLPVLG 480
VLFLLYCFTK QSVSHIRSLC QEILLWILGK LERKKAIASL KGFAGLDKAV PSLHSLCQFR 540
VATQGGIMIT IKEAISDEDE DEALYQKVSS EQGRVEHLGD LLSHCQECGL AGDFFIFCLK 600
ELTHVASENE TELKTEPFSS KSLLELEQHQ TLLVEGQERK LLVLQLMAVL CERMSEQIFT 660
NVTQVVDFVA ATLQRACASL AHQAESTVES QTLSMSMGLV AVMLGGAVQL KSSDFAVLKQ 720
LLPLLEKVSN TYPDPVIQEL AVDLRITIST HGAFATEAVS MAAQSTLNRK DLEGKIEEQQ 780
QTSHERPTDV AHSHLEQQQS HETAPQTGLQ SNAPIIPQGV NEPSTTTSQK SGSVTTEQLQ 840
EVLLSAYDPQ IPTRAAALRT LSHWIEQREA KALEMQEKLL KIFLENLEHE DTFVYLSAIQ 900
GVALLSDVYP EKILPDLLAQ YDSSKDKHTP ETRMKVGEVL MRIVRALGDM VSKYREPLIH 960
TFLRGVRDPD GAHRASSLAN LGELCQRLDF LLGSVVHEVT ACLIAVAKTD GEVQVRRAAI 1020
HVVVLLLRGL SQKATEVLSA VLKDLYHLLK HVVCLEPDDV AKLHAQLALE ELDDIMKNFL 1080
FPPQKLEKKI MVLP 1094 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR019414; DUF2411. 
Pfam
 PF10304; DUF2411 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS