CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041579
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hepatocyte nuclear factor 4, alpha, isoform CRA_a 
Protein Synonyms/Alias
 Hepatocyte nuclear factor 4-alpha 
Gene Name
 Hnf4a 
Gene Synonyms/Alias
 rCG_32146 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
458GAITTIVKPPSAIPQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 474 AA 
Protein Sequence
MRLSKTLADM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGANLNS SNSLGVSALC 60
AICGDRATGK HYGASSCDGC KGFFRRSVRK NHMYSCRFSR QCVVDKDKRN QCRYCRLKKC 120
FRAGMKKEAV QNERDRISTR RSSYEDSSLP SINALLQAEV LSQQITSPIS GINGDIRAKR 180
IANITDVCES MKEQLLVLVE WAKYIPAFCE LLLDDQVALL RAHAGEHLLL GATKRSMVFK 240
DVLLLGNDYI VPRHCPELAE MSRVSIRILD ELVLPFQELQ IDDNEYACLK AIIFFDPDAK 300
GLSDPGKIKR LRSQVQVSLE DYINDRQYDS RGRFGELLLL LPTLQSITWQ MIEQIQFIKL 360
FGMAKIDNLL QEMLLGGSAS DAPHAHHPLH PHLMQEHMGT NVIVANTMPS HLSNGQMCEW 420
PRPRGQAATP ETPQPSPPSG SGSESYKLLP GAITTIVKPP SAIPQPTITK QEAI 474 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0005504; F:fatty acid binding; IEA:Compara.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:InterPro.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007596; P:blood coagulation; IEA:Compara.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0030522; P:intracellular receptor signaling pathway; IEA:GOC.
 GO:0006629; P:lipid metabolic process; IEA:Compara.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0006591; P:ornithine metabolic process; IEA:Compara.
 GO:0055091; P:phospholipid homeostasis; IEA:Compara.
 GO:2000189; P:positive regulation of cholesterol homeostasis; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0010470; P:regulation of gastrulation; IEA:Compara.
 GO:0050796; P:regulation of insulin secretion; IEA:Compara.
 GO:0019216; P:regulation of lipid metabolic process; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0007548; P:sex differentiation; IEA:Compara.
 GO:0023019; P:signal transduction involved in regulation of gene expression; IEA:Compara.
 GO:0060395; P:SMAD protein signal transduction; IEA:Compara.
 GO:0070328; P:triglyceride homeostasis; IEA:Compara.
 GO:0006805; P:xenobiotic metabolic process; IEA:Compara. 
Interpro
 IPR003068; COUP_TF.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR01282; COUPTNFACTOR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.