CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043932
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serrate RNA effector molecule homolog 
Protein Synonyms/Alias
  
Gene Name
 SRRT 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
106FDRSVNIKEICWNLQubiquitination[1, 2, 3]
144INGITQHKQIVRNDIubiquitination[2, 3]
156NDIKLAAKLIHTLDDacetylation[3, 4]
156NDIKLAAKLIHTLDDubiquitination[2, 5]
241KLIKVLDKLLLYLRIubiquitination[2]
299WQKTFEEKLTPLLSVubiquitination[2]
317LSEEEAQKMGRKDPEacetylation[4]
317LSEEEAQKMGRKDPEubiquitination[2, 3]
340SNTQELGKDKWLCPLacetylation[3, 4]
Reference
 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 499 AA 
Protein Sequence
ESESESGQAE EEKEEAEEAL KEKEKPKEEE WEKPKDAAGL ECKPRPLHKT CSLFMRNIAP 60
NISRAEIISL CKRYPGFMRV ALSEPQPERR FFRRGWVTFD RSVNIKEICW NLQNIRLREC 120
ELSPGVNRDL TRRVRNINGI TQHKQIVRND IKLAAKLIHT LDDRTQLWAS EPGTPPLPTS 180
LPSQNPILKN ITDYLIEEVS AEEEELLGSS GGAPPEEPPK EGNPAEINVE RDEKLIKVLD 240
KLLLYLRIVH SLDYYNTCEY PNEDEMPNRC GIIHVRGPMP PNRISHGEVL EWQKTFEEKL 300
TPLLSVRESL SEEEAQKMGR KDPEQEVEKF VTSNTQELGK DKWLCPLSGK KFKGPEFVRK 360
HIFNKHAEKI EEVKKEVAFF NNFLTDAKRP ALPEIKPAQP PGPAQILPPG LTPGLPYPHQ 420
TPQGLMPYGQ PRPPILGYGV PTGGPPYPHA PYGAGRGNYD AFRGQGGYPG KPRNRMVRGD 480
PRAIVEYRDL DAPDDVDFF 499 
Gene Ontology
  
Interpro
 IPR007042; Arsenite-R_2. 
Pfam
 PF04959; ARS2 
SMART
  
PROSITE
  
PRINTS