| Tag | Content |
|---|
| CPLM ID | CPLM-016871 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | PH domain leucine-rich repeat-containing protein phosphatase 1 |
Protein Synonyms/Alias | Pleckstrin homology domain-containing family E member 1; PH domain-containing family E member 1; Suprachiasmatic nucleus circadian oscillatory protein |
Gene Name | Phlpp1 |
Gene Synonyms/Alias | Kiaa0606; Phlpp; Plekhe1; Scop |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 102 | GANSLLLKRGRLKRN | ubiquitination | [1] | | 215 | RLLQLGHKGGGVVKV | ubiquitination | [1] | | 421 | RIRETVQKTSPPSLY | ubiquitination | [1] | | 1102 | PRLALDHKSLELLNN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB, and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). |
Sequence Annotation | DOMAIN 492 592 PH.
REPEAT 594 615 LRR 1.
REPEAT 617 638 LRR 2.
REPEAT 648 669 LRR 3.
REPEAT 671 692 LRR 4.
REPEAT 694 715 LRR 5.
REPEAT 717 739 LRR 6.
REPEAT 740 760 LRR 7.
REPEAT 764 785 LRR 8.
REPEAT 788 809 LRR 9.
REPEAT 829 850 LRR 10.
REPEAT 851 872 LRR 11.
REPEAT 874 895 LRR 12.
REPEAT 897 918 LRR 13.
REPEAT 919 940 LRR 14.
REPEAT 943 964 LRR 15.
REPEAT 969 989 LRR 16.
REPEAT 993 1014 LRR 17.
REPEAT 1017 1038 LRR 18.
REPEAT 1040 1061 LRR 19.
REPEAT 1062 1083 LRR 20.
REPEAT 1085 1106 LRR 21.
DOMAIN 1121 1376 PP2C-like.
MOTIF 1685 1687 PDZ-binding.
METAL 1166 1166 Manganese 1 (By similarity).
METAL 1166 1166 Manganese 2 (By similarity).
METAL 1167 1167 Manganese 1; via carbonyl oxygen (By
METAL 1330 1330 Manganese 2 (By similarity).
METAL 1369 1369 Manganese 2 (By similarity). |
Keyword | Apoptosis; Complete proteome; Cytoplasm; Hydrolase; Leucine-rich repeat; Manganese; Membrane; Metal-binding; Nucleus; Protein phosphatase; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1687 AA |
Protein Sequence | MEPAAAAPAQ RLADPTGEDQ ALAAAAAEGG RCPDPALSAA APSGGNGGAA REEAPCEAPP 60
GPLPGRAGGT GRRRRRGAPQ PAAGGAAPVP AAGGGANSLL LKRGRLKRNL SAAAAASSSS 120
SPSSASSAAG GLPASCSASA SLCTRSLDRK TLLLKHRQLL QLQPSDRDWV RHQLQRGCVH 180
VFDRHMASSY LRPVLCTLDT TAAEVAARLL QLGHKGGGVV KVLGYGPPPA AAPAASDQTL 240
DGEHGRDVEP PPSSGTVGAV RGPARAPPAD LPLPGGAWTR CAPRISPAPS DSSPGELFAG 300
GPGSPPRAPR PASDTESFSL SPSAESVSDR LDPYSSGGGG SSSSSEELEA DPAMPHRPGR 360
PAQPRPPSPK TSALLQPKAP TGVDSTGVIA GEGPGDDKAM AAAAPDVPLS TSGRIRETVQ 420
KTSPPSLYVQ LHGETTRRLE ADEKPLQIQN DYLFQLGFGE LWRVQEEGMD SEIGCLIRFY 480
AGKPHSTGSS ERIQLSGMYN VRKGKMQLPV NRWTRRQVIL CGTCLIVSSV KDSVSGKMHV 540
LPLIGGKVEE VKKHQHCLAF SSSGPQSQTY YICFDTFTEY LRWLRQVSKV ASQRISSVDL 600
SCCSLEHLPA NLFYSQDLTH LNLKQNFLRQ TPTLPAARGL GELQRFTKLK SLNLSNNHLG 660
AFPSAVCSIP TLAELNVSCN ALREVPAAVG DMQNLQTFLL DGNFLQSLPA ELESMHQLSY 720
LGLSFNEFTD IPEVLEKLTA VDKLCMAGNC VETLRLQALR RMPHIKHVDL RLNILRKLMA 780
DEVDFVQHVT QLDLRDNKLG DLDAMIFNNI EVLHCERNQL VTLNVCGYFL KALYASSNEL 840
AQLDVYPVPN YLSYMDVSRN CLESVPEWVC ESRKLEVLDI GHNQICELPA RLFCNSSLRK 900
LLAGHNRLAR LPERLERTSV EVLDVQHNQI TELPPNLLMK ADSLRFLNAS ANKLETLPPA 960
TLSEETSSIL QELYLTNNCL TDKCVPLLTG HPRLKILHMA YNRLQSFPAS KMAKLEELEE 1020
IDISGNKLKA IPTTIMNCRR MHTVIAHSNC IEVFPEVMQL PEVKCVDLSC NELSEITLPE 1080
NLPPKLQELD LTGNPRLALD HKSLELLNNI RCFKIDQPSA GDASGAPAVW SHGYTEASGV 1140
KNKLCVAALS VNNFRDNREA LYGVFDGDRN VEVPYLLQCT MSDILAEELQ KTKNEEEYMV 1200
NTFIVMQRKL GTAGQKLGGA AVLCHIKPDP VDLGGSFTLT SANVGKCQTV LCRNGKPLSL 1260
SRSYIMSCEE ERKRIKQHKA IITEDGKVNG VTESTRILGY TFLHPSVVPR PHVQSVLLTP 1320
QDEFFILGSK GLWDSLSIDE AVEAVRNVPD ALAAAKKLCT LAQSYGCHDS ISAVVVQLSV 1380
TEDSFCCCEL SAGGSMPPPS PGIFPPSVNM VIKDRPSDGL GVPSSSSGMA SEISSELSTS 1440
EMSSEVGSTA SDEPPSGVLN ESSPAYPNEQ RCMLHPVCLS NSFQRQLSSA TFSSAFSDNG 1500
LDSDDEEPIE GVFSNGSRVE VEVDIHCSRA KEKERQQHLL QVPAEASDEG IVISANEDES 1560
GLSKKADFSA VGTIGRRRAN GSVAPQERSH NVIEVAADAP LRKPGGYFAA PAQPDPDDQF 1620
IIPPELEEEV KEIMKHHQEQ QQQQQQQQLP PPPQPPQPQP QPQPQPQPQP QRHFQMDHLP 1680
DCYDTPL 1687 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0009649; P:entrainment of circadian clock; IMP:MGI. GO:0008152; P:metabolic process; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |