CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008445
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 V-type proton ATPase subunit d 1 
Protein Synonyms/Alias
 V-ATPase subunit d 1; P39; Physophilin; V-ATPase 40 kDa accessory protein; V-ATPase AC39 subunit; Vacuolar proton pump subunit d 1 
Gene Name
 Atp6v0d1 
Gene Synonyms/Alias
 Atp6d 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
73TVSVIDDKLKEKMVVubiquitination[1]
187IIRNTLYKAYLESFYubiquitination[1]
265ADDYEQVKNVADYYPubiquitination[1]
275ADYYPEYKLLFEGAGubiquitination[1]
288AGSNPGDKTLEDRFFubiquitination[1]
343IAQRHRAKIDNYIPIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). 
Sequence Annotation
 MOD_RES 270 270 Phosphotyrosine.
 MOD_RES 283 283 Phosphoserine.  
Keyword
 Cilium biogenesis/degradation; Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Membrane; Phosphoprotein; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 351 AA 
Protein Sequence
MSFFPELYFN VDNGYLEGLV RGLKAGVLSQ ADYLNLVQCE TLEDLKLHLQ STDYGNFLAN 60
EASPLTVSVI DDKLKEKMVV EFRHMRNHAY EPLASFLDFI TYSYMIDNVI LLITGTLHQR 120
SIAELVPKCH PLGSFEQMEA VNIAQTPAEL YNAILVDTPL AAFFQDCISE QDLDEMNIEI 180
IRNTLYKAYL ESFYKFCTLL GGTTADAMCP ILEFEADRRA FIITINSFGT ELSKEDRAKL 240
FPHCGRLYPE GLAQLARADD YEQVKNVADY YPEYKLLFEG AGSNPGDKTL EDRFFEHEVK 300
LNKLAFLNQF HFGVFYAFVK LKEQECRNIV WIAECIAQRH RAKIDNYIPI F 351 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0043679; C:axon terminus; IEA:Compara.
 GO:0005769; C:early endosome; IDA:MGI.
 GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0008553; F:hydrogen-exporting ATPase activity, phosphorylative mechanism; IDA:MGI.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0042384; P:cilium assembly; ISS:UniProtKB. 
Interpro
 IPR002843; ATPase_V0-cplx_csu/dsu.
 IPR016727; ATPase_V0-cplx_dsu. 
Pfam
 PF01992; vATP-synt_AC39 
SMART
  
PROSITE
  
PRINTS