CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004522
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 25 
Protein Synonyms/Alias
 Zinc finger protein KOX19 
Gene Name
 ZNF25 
Gene Synonyms/Alias
 KOX19 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
265YECKECGKAFSQKSHacetylation[1]
284QRMHTGEKPYKCKECacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 8 79 KRAB.
 ZN_FING 118 140 C2H2-type 1.
 ZN_FING 146 168 C2H2-type 2.
 ZN_FING 174 196 C2H2-type 3.
 ZN_FING 202 224 C2H2-type 4.
 ZN_FING 230 252 C2H2-type 5.
 ZN_FING 258 280 C2H2-type 6.
 ZN_FING 286 308 C2H2-type 7.
 ZN_FING 314 336 C2H2-type 8.
 ZN_FING 342 364 C2H2-type 9.
 ZN_FING 370 392 C2H2-type 10.
 ZN_FING 398 420 C2H2-type 11.
 ZN_FING 426 448 C2H2-type 12.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 456 AA 
Protein Sequence
MNKFQGPVTL KDVIVEFTKE EWKLLTPAQR TLYKDVMLEN YSHLVSVGYH VNKPNAVFKL 60
KQGKEPWILE VEFPHRGFPE DLWSIHDLEA RYQESQAGNS RNGELTKHQK THTTEKACEC 120
KECGKFFCQK SALIVHQHTH SKGKSYDCDK CGKSFSKNED LIRHQKIHTR DKTYECKECK 180
KIFYHLSSLS RHLRTHAGEK PYECNQCEKS FYQKPHLTEH QKTHTGEKPF ECTECGKFFY 240
VKAYLMVHQK THTGEKPYEC KECGKAFSQK SHLTVHQRMH TGEKPYKCKE CGKFFSRNSH 300
LKTHQRSHTG EKPYECKECR KCFYQKSALT VHQRTHTGEK PFECNKCGKT FYYKSDLTKH 360
QRKHTGEKPY ECTECGKSFA VNSVLRLHQR THTGEKPYAC KECGKSFSQK SHFIIHQRKH 420
TGEKPYECQE CGETFIQKSQ LTAHQKTHTK KRNAEK 456 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB
 PF00096; zf-C2H2 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS