UniProt Accession

 SCRN1_HUMAN; Q12765; A8K0E9; B4DHM0; B4DIP5; C9JPG0; Q25QX7; Q8IWD1 

Genbank Protein ID

 AB071705; D83777; AK289514; AK295172; AK295713; AC004912; AC007285; CH471073; CH471073; BC040492 

Genbank Nucleotide ID

 BAE91926.1; BAA12106.2; BAF82203.1; BAG58182.1; BAG58557.1; AAQ96874.1; EAW93926.1; EAW93928.1; AAH40492.1 

Protein Name

 Secernin-1 

Protein Synonyms/Alias

  

Gene Name

 SCRN1 

Gene Synonyms/Alias

 KIAA0193 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
18	VAFPPRAKDGLVVFG	ubiquitination	[1]
179	GKYWAAEKVTEGVRC	ubiquitination	[2]
306	DPSRSIFKPFIFVDD	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity). 

Sequence Annotation

 ACT_SITE 9 9 Potential.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Exocytosis; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 414 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0031965; C:nuclear membrane; IDA:UniProtKB.
 GO:0016805; F:dipeptidase activity; IEA:InterPro.
 GO:0006887; P:exocytosis; ISS:UniProtKB.
 GO:0006508; P:proteolysis; IEA:InterPro. 

Interpro

 IPR005322; Peptidase_C69. 

Pfam

 PF03577; Peptidase_C69 

SMART

  

PROSITE

  

PRINTS