CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001999
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myelin basic protein 
Protein Synonyms/Alias
 MBP 
Gene Name
 Mbp 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
14PSQRHGSKYLATASTacetylation[1]
64SGKVPWLKQSRSPLPacetylation[1]
85PGLCHMYKDSHTRTTacetylation[1]
100HYGSLPQKSQRTQDEacetylation[1]
100HYGSLPQKSQRTQDEubiquitination[2]
115NPVVHFFKNIVTPRTacetylation[1]
146SWGAEGQKPGFGYGGacetylation[1]
146SWGAEGQKPGFGYGGubiquitination[2]
166KSAHKGFKGAYDAQGacetylation[1]
177DAQGTLSKIFKLGGRacetylation[1]
180GTLSKIFKLGGRDSRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
 Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 8 8 Phosphoserine (By similarity).
 MOD_RES 13 13 Phosphoserine (By similarity).
 MOD_RES 26 26 Citrulline (By similarity).
 MOD_RES 32 32 Citrulline (By similarity).
 MOD_RES 36 36 Phosphothreonine (By similarity).
 MOD_RES 41 41 Phosphoserine (By similarity).
 MOD_RES 47 47 Phosphoserine (By similarity).
 MOD_RES 57 57 Phosphoserine (By similarity).
 MOD_RES 94 94 Phosphotyrosine (By similarity).
 MOD_RES 96 96 Phosphoserine (By similarity).
 MOD_RES 119 119 Phosphothreonine.
 MOD_RES 122 122 Phosphothreonine (By similarity).
 MOD_RES 127 127 Deamidated glutamine (By similarity).
 MOD_RES 131 131 Omega-N-methylarginine; alternate.
 MOD_RES 131 131 Symmetric dimethylarginine; alternate.
 MOD_RES 139 139 Phosphoserine (By similarity).
 MOD_RES 146 146 N6-acetyllysine (By similarity).
 MOD_RES 154 154 Citrulline (By similarity).
 MOD_RES 172 172 Deamidated glutamine (By similarity).
 MOD_RES 184 184 Citrulline (By similarity).
 MOD_RES 186 186 Phosphoserine (By similarity).
 MOD_RES 190 190 Phosphoserine; by UHMK1 (By similarity).
 MOD_RES 195 195 Citrulline (By similarity).  
Keyword
 Acetylation; Alternative splicing; Autoimmune encephalomyelitis; Cell membrane; Citrullination; Complete proteome; Direct protein sequencing; Membrane; Methylation; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 195 AA 
Protein Sequence
MASQKRPSQR HGSKYLATAS TMDHARHGFL PRHRDTGILD SIGRFFSGDR GAPKRGSGKV 60
PWLKQSRSPL PSHARSRPGL CHMYKDSHTR TTHYGSLPQK SQRTQDENPV VHFFKNIVTP 120
RTPPPSQGKG RGLSLSRFSW GAEGQKPGFG YGGRASDYKS AHKGFKGAYD AQGTLSKIFK 180
LGGRDSRSGS PMARR 195 
Gene Ontology
 GO:0043218; C:compact myelin; IDA:RGD.
 GO:0033269; C:internode region of axon; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0019911; F:structural constituent of myelin sheath; IMP:RGD.
 GO:0061024; P:membrane organization; IEA:Compara.
 GO:0042552; P:myelination; IMP:RGD.
 GO:0050771; P:negative regulation of axonogenesis; IMP:RGD.
 GO:0009636; P:response to toxic substance; IEA:Compara. 
Interpro
 IPR000548; Myelin_BP. 
Pfam
 PF01669; Myelin_MBP 
SMART
  
PROSITE
 PS00569; MYELIN_MBP 
PRINTS
 PR00212; MYELINMBP.