Tag | Content |
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CPLM ID | CPLM-000562 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Peroxiredoxin-6 |
Protein Synonyms/Alias | 1-Cys peroxiredoxin; 1-Cys PRX; Acidic calcium-independent phospholipase A2; aiPLA2; Antioxidant protein 2; Non-selenium glutathione peroxidase; NSGPx; Thiol-specific antioxidant protein |
Gene Name | Prdx6 |
Gene Synonyms/Alias | Aipla2; Aop2; Tsa |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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56 | TELGRAAKLAPEFAK | acetylation | [1] | 63 | KLAPEFAKRNVKLIA | acetylation | [1] | 97 | NGAAPTEKLPFPIID | acetylation | [1] | 141 | VFIFGPDKKLKLSIL | acetylation | [1] | 182 | VATPVDWKKGESVMV | acetylation | [1] | 204 | EAKQLFPKGVFTKEL | acetylation | [1] | 209 | FPKGVFTKELPSGKK | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. |
Sequence Annotation | DOMAIN 5 169 Thioredoxin. ACT_SITE 32 32 For phospholipase activity (By ACT_SITE 47 47 Cysteine sulfenic acid (-SOH) MOD_RES 44 44 Phosphothreonine (By similarity). MOD_RES 63 63 N6-acetyllysine (By similarity). MOD_RES 89 89 Phosphotyrosine (By similarity). MOD_RES 209 209 N6-acetyllysine (By similarity). DISULFID 47 47 Interchain; in linked form (By |
Keyword | Acetylation; Antioxidant; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; Disulfide bond; Hydrolase; Lipid degradation; Lipid metabolism; Lysosome; Multifunctional enzyme; Oxidoreductase; Peroxidase; Phosphoprotein; Redox-active center; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 224 AA |
Protein Sequence | MPGGLLLGDE APNFEANTTI GHIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE 60 FAKRNVKLIA LSIDSVEDHF AWSKDINAYN GAAPTEKLPF PIIDDKDRDL AILLGMLDPA 120 EKDEKGMPVT ARVVFIFGPD KKLKLSILYP ATTGRNFDEI LRVVDSLQLT ASNPVATPVD 180 WKKGESVMVL PTLPEEEAKQ LFPKGVFTKE LPSGKKYLRY TPQP 224 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell. GO:0005764; C:lysosome; IEA:UniProtKB-SubCell. GO:0004602; F:glutathione peroxidase activity; IDA:RGD. GO:0051920; F:peroxiredoxin activity; IEA:EC. GO:0004623; F:phospholipase A2 activity; IEA:Compara. GO:0042744; P:hydrogen peroxide catabolic process; IDA:RGD. GO:0009395; P:phospholipid catabolic process; IEA:Compara. |
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