CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009578
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ras-related protein Rap-1A 
Protein Synonyms/Alias
 Ras-related protein Krev-1 
Gene Name
 Rap1a 
Gene Synonyms/Alias
 Krev-1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
5***MREYKLVVLGSGubiquitination[1]
31VQGIFVEKYDPTIEDubiquitination[1]
117PMILVGNKCDLEDERubiquitination[1]
128EDERVVGKEQGQNLAubiquitination[1]
149AFLESSAKSKINVNEubiquitination[1]
151LESSAKSKINVNEIFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). 
Sequence Annotation
 NP_BIND 10 17 GTP (By similarity).
 NP_BIND 57 61 GTP (By similarity).
 NP_BIND 116 119 GTP (By similarity).
 MOTIF 32 40 Effector region (Probable).
 MOD_RES 181 181 Cysteine methyl ester (By similarity).
 LIPID 181 181 S-geranylgeranyl cysteine (By  
Keyword
 Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Reference proteome; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 184 AA 
Protein Sequence
MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDCQQ CMLEILDTAG 60
TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTEDVP MILVGNKCDL 120
EDERVVGKEQ GQNLARQWCN CAFLESSAKS KINVNEIFYD LVRQINRKTP VEKKKPKKKS 180
CLLL 184 
Gene Ontology
 GO:0032045; C:guanyl-nucleotide exchange factor complex; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IDA:MGI.
 GO:0032403; F:protein complex binding; ISS:UniProtKB.
 GO:0008565; F:protein transporter activity; ISS:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 
Pfam
 PF00071; Ras 
SMART
 SM00173; RAS 
PROSITE
 PS51421; RAS 
PRINTS
 PR00449; RASTRNSFRMNG.